CD167 antibody
Rabbit anti Human CD167 antibody detects an epitope within the C-terminal of human CD167, a Discoidin Domain Receptor (DDR) also known as DDR1. CD167, a receptor for collagen, is widely expressed in normal and transformed epithelial cells, and may regulate cell adhesion, proliferation and extracellular matrix remodelling.
CD167 is a ~125 kDa protein which is partially processed into a 62 kDa membrane-anchored beta-subunit and a 54 kDa soluble alpha-subunit. This process, also termed shedding, is significantly enhanced upon CD167 activation.
CD167 has been demonstrated to be a direct transcriptional target of the p53 tumour suppressor gene, and is significantly over-expressed in breast, ovarian, oesophageal, and paediatric brain tumours.
CD167 is a ~125 kDa protein which is partially processed into a 62 kDa membrane-anchored beta-subunit and a 54 kDa soluble alpha-subunit. This process, also termed shedding, is significantly enhanced upon CD167 activation.
CD167 has been demonstrated to be a direct transcriptional target of the p53 tumour suppressor gene, and is significantly over-expressed in breast, ovarian, oesophageal, and paediatric brain tumours.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to CD167 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide: C-terminal region of human CD167.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Shelf Life
- 18 months from date of despatch.
More Information
- UniProt
- Q08345 Related reagents
- Entrez Gene
- DDR1 Related reagents
- Regulatory
- For research purposes only
Applications of CD167 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin 1 | 20 | 30ug/ml |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Decidual cells.
Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
| Description | Product Code | Pack Size | Applications | List Price | Quantity |
|---|---|---|---|---|---|
| Sheep anti Rabbit IgG:Biotin | 2AB02B | 1 ml | C E P WB | ||
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | 1 mg | E WB | ||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | 1 mg | F | ||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | 1 mg | E WB | ||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | 1 mg | C E WB | ||
| Sheep anti Rabbit IgG:FITC | STAR34B | 1 mg | C F | ||
| Sheep anti Rabbit IgG:RPE | STAR35A | 1 ml | F | ||
| Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | 0.1 mg | F IF WB | ||
| Sheep anti Rabbit IgG:DyLight®549 | STAR36D549GA | 0.1 mg | F IF | ||
| Sheep anti Rabbit IgG:DyLight®649 | STAR36D649GA | 0.1 mg | F IF | ||
| Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | 0.1 mg | F IF WB | ||
| Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | 0.1 mg | F IF WB |
Useful Reagents Available
| Description | Product Code | Pack Size | Applications | List Price | Quantity |
|---|---|---|---|---|---|
| Histar Detection System | STAR3000A | 50 Tests | C P | ||
| Histar Detection System | STAR3000B | 150 Tests | C P | ||
| Histar Detection System | STAR3000C | 500 Tests | C P |
Product Specific References
References for CD167 antibody
-
Vogel, W.F. et al. (2006) Sensing extracellular matrix: an update on discoidin domain receptor function.
Cell Signal. 18 (8): 1108-16. -
Valencia, K. et al. (2012) Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces cell survival, homing, and colonization in lung cancer bone metastasis.
Clin Cancer Res. 18 (4): 969-80.
