CD156c antibody

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Rabbit anti Human CD156c

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP586 WB 0.1 mg
Rabbit anti Human CD156c antibody recognizes human Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM-10, CDw156, Mammalian disintegrin-metalloprotease, CD156c or Kuzbanian protein homolog. CD156c is a 748 amino acid ~85 kDa type I, single pass transmembrane glycoprotein with a 19 aa signal peptide and adjacent 194 aa propeptide region yeilding a mature 535 aa protease. CD156c is a member of the mammalian ADAM family and is involved in the cleavage of TNF alpha, Notch and its ligand delta (Primakoff & Miles 2000).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to CD156c (CT) were raised by repeated immunisation of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
Peptide corresponding to amino acids 732-748 of human CD156c.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
O14672 Related reagents
Entrez Gene
ADAM10 Related reagents
GO Terms
GO:0005886 plasma membrane
GO:0001701 in utero embryonic development
GO:0004222 metalloendopeptidase activity
GO:0016021 integral to membrane
GO:0005178 integrin binding
GO:0005634 nucleus
GO:0005798 Golgi-associated vesicle
GO:0006468 protein phosphorylation
GO:0007162 negative regulation of cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0007229 integrin-mediated signaling pathway
GO:0007267 cell-cell signaling
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell proliferation
GO:0009986 cell surface
GO:0010820 positive regulation of T cell chemotaxis
GO:0012505 endomembrane system
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030307 positive regulation of cell growth
GO:0034612 response to tumor necrosis factor
GO:0042117 monocyte activation
GO:0042803 protein homodimerization activity
GO:0051088 PMA-inducible membrane protein ectodomain proteolysis
GO:0051089 constitutive protein ectodomain proteolysis
Regulatory
For research purposes only

Applications of CD156c antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB

Useful Reagents Available

Description Product Code Pack Size Applications List Price Quantity
TidyBlot™ Western Blot Detection Reagent:HRP STAR209P 0.5 ml WB*

Product Specific References

Further Reading

  1. Rosendahl, M.S. et al. (1997) Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases.
    J Biol Chem. 272 (39): 24588-93.