Rabbit anti Human CD156c antibody
recognizes human Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM-10, CDw156, Mammalian disintegrin-metalloprotease, CD156c or Kuzbanian protein homolog. CD156c is a 748 amino acid ~85 kDa type I, single pass transmembrane glycoprotein with a 19 aa signal peptide and adjacent 194 aa propeptide region yeilding a mature 535 aa protease. CD156c is a member of the mammalian ADAM
family and is involved in the cleavage of TNF alpha, Notch and its ligand delta (Primakoff & Miles 2000
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to CD156c (CT) were raised by repeated immunisation of rabbit with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Peptide corresponding to amino acids 732-748 of human CD156c.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
in utero embryonic development
integral to membrane
negative regulation of cell adhesion
epidermal growth factor receptor signaling pathway
Notch signaling pathway
Notch receptor processing
integrin-mediated signaling pathway
zinc ion binding
positive regulation of cell proliferation
positive regulation of T cell chemotaxis
SH3 domain binding
protein kinase binding
positive regulation of cell growth
response to tumor necrosis factor
protein homodimerization activity
PMA-inducible membrane protein ectodomain proteolysis
constitutive protein ectodomain proteolysis
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD156c antibody
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Rosendahl, M.S. et al. (1997) Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases.
J Biol Chem. 272 (39): 24588-93.
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