CBX5 antibody

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Anti CBX5 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with CBX5 antibody followed by detection with HRP conjugated Goat anti Rabbit IgG antibody (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 16 second exposure. Arrow points to CBX5 (molecular weight 26 kDa).

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Rabbit anti CBX5

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: CBX5

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VPA00452 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human CBX5 antibody recognizes CBX5, also known as heterochromatin protein 1 homolog alpha, HP1-alpha, chromobox protein homolog 5, antigen p25 or epididymis luminal protein 25.

The CBX5 gene encodes a highly conserved nonhistone protein, a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified (provided by RefSeq, Jul 2008).

Rabbit anti Human CBX5 antibody detects a band of 26 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti CBX5 detects a band of approximately 26 kDa in HeLa cell lysates.
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid.
Preparation: Rabbit polyclonal antibody prepared by affinity chromatography on Protein A.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
2% Sucrose.
Immunogen: Synthetic peptide directed towards the middle region of human CBX5
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Mouse

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: P45973
Entrez Gene: CBX5
GO Terms: GO:0000118 histone deacetylase complex; GO:0006333 chromatin assembly or disassembly; GO:0030674 protein binding, bridging; GO:0007596 blood coagulation; GO:0005635 nuclear envelope; GO:0005737 cytoplasm; GO:0005730 nucleolus; GO:0016565 general transcriptional repressor activity; GO:0017053 transcriptional repressor complex; View More GO Terms; GO:0031618 nuclear centromeric heterochromatin; GO:0035064 methylated histone residue binding; GO:0035097 histone methyltransferase complex; GO:0044419 interspecies interaction between organisms; GO:0070491 repressing transcription factor binding