Caveolin 1 antibody
Caveolin-1 has been implicated in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis and functions as a tumour and/or metastasis-modifying gene (Williams and Lisanti 2005).
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Dog Pig Rat Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to Caveolin 1 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
0.05% Bovine Serum Albumin - Immunogen
- Synthetic peptide sequence DELSEKQVYDAH (aa 34-45) corresponding to an internal domain of human Caveolin 1.
- Approx. Protein Concentrations
- Total protein concentration 0.5mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q03135
- Entrez Gene
- CAV1
- GO Terms
- GO:0000139 Golgi membrane
- GO:0000188 inactivation of MAPK activity
- GO:0005515 protein binding
- GO:0001570 vasculogenesis
- GO:0001666 response to hypoxia
- GO:0001937 negative regulation of endothelial cell proliferation
- GO:0007596 blood coagulation
- GO:0005102 receptor binding
- GO:0005783 endoplasmic reticulum
- GO:0005811 lipid particle
- GO:0005901 caveola
- GO:0006641 triglyceride metabolic process
- GO:0006816 calcium ion transport
- GO:0006940 regulation of smooth muscle contraction
- GO:0007519 skeletal muscle tissue development
- GO:0009267 cellular response to starvation
- GO:0010524 positive regulation of calcium ion transport into cytosol
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0015485 cholesterol binding
- GO:0016050 vesicle organization
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0016504 peptidase activator activity
- GO:0019217 regulation of fatty acid metabolic process
- GO:0019915 lipid storage
- GO:0030193 regulation of blood coagulation
- GO:0030514 negative regulation of BMP signaling pathway
- GO:0030857 negative regulation of epithelial cell differentiation
- GO:0031295 T cell costimulation
- GO:0031623 receptor internalization
- GO:0032091 negative regulation of protein binding
- GO:0032507 maintenance of protein location in cell
- GO:0032570 response to progesterone stimulus
- GO:0032947 protein complex scaffold
- GO:0033137 negative regulation of peptidyl-serine phosphorylation
- GO:0033138 positive regulation of peptidyl-serine phosphorylation
- GO:0033484 nitric oxide homeostasis
- GO:0042632 cholesterol homeostasis
- GO:0051260 protein homooligomerization
- GO:0043409 negative regulation of MAPKKK cascade
- GO:0043627 response to estrogen stimulus
- GO:0044419 interspecies interaction between organisms
- GO:0045019 negative regulation of nitric oxide biosynthetic process
- GO:0045907 positive regulation of vasoconstriction
- GO:0046209 nitric oxide metabolic process
- GO:0048471 perinuclear region of cytoplasm
- GO:0048554 positive regulation of metalloenzyme activity
- GO:0050900 leukocyte migration
- GO:0050998 nitric-oxide synthase binding
- GO:0050999 regulation of nitric-oxide synthase activity
- GO:0051480 cytosolic calcium ion homeostasis
- GO:0051592 response to calcium ion
- GO:0051899 membrane depolarization
- GO:0060056 mammary gland involution
- GO:0070836 caveola assembly
- GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
- GO:0090263 positive regulation of canonical Wnt receptor signaling pathway
- Regulatory
- For research purposes only
Applications of Caveolin 1 antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | 1:32000 | ||
Immunohistology - Paraffin | 2.5ug/ml | ||
Western Blotting | 0.3 | 1.0ug/ml |
- Immunohistology
- This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
- Histology Positive Control Tissue
- Human heart
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Donkey anti Sheep/Goat IgG:HRP | STAR88P | C E P WB | 1 ml |
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Useful Reagents Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Antigen Retrieval Buffer, pH8.0 | BUF025A | P | 500 ml | ||
Antigen Retrieval Buffer, pH8.0 | BUF025C | P | 50 ml | ||
Histar Detection System | STAR3000A | C P | 50 Tests |
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