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Caveolin 1 antibody

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Anti Caveolin 1 Antibody gallery image 1
Staining of formalin fixed, paraffin embedded human heart with Rabbit anti Human caveolin-1 (AHP2048)

Goat anti Caveolin 1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product Code Applications Pack Size List Price Quantity
AHP2048
Datasheet
E P WB
SDS
50 µg loader

Goat anti Human caveolin-1 antibody recognizes human caveolin-1, a ~21 kDa scaffolding protein, the main component of caveolae; endocytic vesicles found in almost all cell types. Caveolin-1 has a number of functions, with important roles in lipid transport, membrane traffic and signal transduction.

Caveolin-1 has been implicated in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis and functions as a tumour and/or metastasis-modifying gene (Williams and Lisanti 2005).

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Dog
Pig
Rat
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to Caveolin 1 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
0.05% Bovine Serum Albumin
Immunogen
Synthetic peptide sequence DELSEKQVYDAH (aa 34-45) corresponding to an internal domain of human Caveolin 1.
Approx. Protein Concentrations
Total protein concentration 0.5mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
Q03135
Entrez Gene
CAV1
GO Terms
GO:0000139 Golgi membrane
GO:0000188 inactivation of MAPK activity
GO:0005515 protein binding
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001937 negative regulation of endothelial cell proliferation
GO:0007596 blood coagulation
GO:0005102 receptor binding
GO:0005783 endoplasmic reticulum
GO:0005811 lipid particle
GO:0005901 caveola
GO:0006641 triglyceride metabolic process
GO:0006816 calcium ion transport
GO:0006940 regulation of smooth muscle contraction
GO:0007519 skeletal muscle tissue development
GO:0009267 cellular response to starvation
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
GO:0015485 cholesterol binding
GO:0016050 vesicle organization
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016504 peptidase activator activity
GO:0019217 regulation of fatty acid metabolic process
GO:0019915 lipid storage
GO:0030193 regulation of blood coagulation
GO:0030514 negative regulation of BMP signaling pathway
GO:0030857 negative regulation of epithelial cell differentiation
GO:0031295 T cell costimulation
GO:0031623 receptor internalization
GO:0032091 negative regulation of protein binding
GO:0032507 maintenance of protein location in cell
GO:0032570 response to progesterone stimulus
GO:0032947 protein complex scaffold
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033484 nitric oxide homeostasis
GO:0042632 cholesterol homeostasis
GO:0051260 protein homooligomerization
GO:0043409 negative regulation of MAPKKK cascade
GO:0043627 response to estrogen stimulus
GO:0044419 interspecies interaction between organisms
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045907 positive regulation of vasoconstriction
GO:0046209 nitric oxide metabolic process
GO:0048471 perinuclear region of cytoplasm
GO:0048554 positive regulation of metalloenzyme activity
GO:0050900 leukocyte migration
GO:0050998 nitric-oxide synthase binding
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051480 cytosolic calcium ion homeostasis
GO:0051592 response to calcium ion
GO:0051899 membrane depolarization
GO:0060056 mammary gland involution
GO:0070836 caveola assembly
GO:0090090 negative regulation of canonical Wnt receptor signaling pathway
GO:0090263 positive regulation of canonical Wnt receptor signaling pathway
Regulatory
For research purposes only

Applications of Caveolin 1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1:32000
Immunohistology - Paraffin 2.5ug/ml
Western Blotting 0.3 1.0ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Immunohistology
This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Histology Positive Control Tissue
Human heart
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Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Donkey anti Sheep/Goat IgG:HRP STAR88P C E P WB 1 ml loader

Useful Reagents Available

Description Product Code Applications Pack Size List Price Quantity
Antigen Retrieval Buffer, pH8.0 BUF025A P 500 ml
Antigen Retrieval Buffer, pH8.0 BUF025C P 50 ml
Histar Detection System STAR3000A C P 50 Tests

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