Calcitonin antibody

Rabbit anti Calcitonin

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
Calcitonin

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VPA00559
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Rabbit anti Human calcitonin antibody recognizes calcitonin, also known as CALCA or alpha-type CGRP.

CALCA gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for CALCA (provided by RefSeq, Nov 2009).

Rabbit anti Human calcitonin antibody detects a band of 17 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti calcitonin detects a band of approximately 17 kDa in HEK293 cell lysates.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH conjugated synthetic peptide corresponding to amino acid 104-132 of human calcitonin
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P01258
Entrez Gene
CALCA
GO Terms
GO:0002548 monocyte chemotaxis
GO:0005179 hormone activity
GO:0005615 extracellular space
GO:0007566 embryo implantation
GO:0016481 negative regulation of transcription
GO:0031716 calcitonin receptor binding
GO:0032147 activation of protein kinase activity
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045779 negative regulation of bone resorption
GO:0051482 elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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