Rabbit anti Human cadherin 13 antibody recognizes human Cadherin 13, a ~78 kDa, calcium-dependent, glycoprotein. While Cadherin 13 is a member of the cadherin family, it lacks their conserved cytoplasmic region, being instead anchored to the plasma membrane via glycosylphosphatidylinositol linkage. It is expressed in the heart and CNS with the exception of the cerebellum and spinal cord.
Cadherin 13 is classified as a cell-cell adhesion molecule, although it is likely that it’s role is in signalling and not physical adhesion. It is involved in regulating low-density lipoprotein-initiated cell proliferation, keratinocyte proliferation, neural cell growth and may play a role in metabolic regulation. Cadherin 13 protects endothelial cells from oxidative stress-induced apoptosis and may contribute to progression of vascular disorders such as atherosclerosis, restenosis and tumour angiogenesis.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to Cadherin 13 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Synthetic peptide corresponding to N-terminus of human Cadherin 13.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
calcium ion binding
positive regulation of endothelial cell proliferation
positive regulation of cell-matrix adhesion
homophilic cell adhesion
negative regulation of cell adhesion
Rho protein signal transduction
calcium-dependent cell-cell adhesion
negative regulation of cell proliferation
anchored to membrane
Rac protein signal transduction
regulation of endocytosis
low-density lipoprotein particle binding
positive regulation of cell migration
cell junction assembly
adherens junction organization
regulation of epidermal growth factor receptor signaling pathway
endothelial cell migration
positive regulation of survival gene product expression
positive regulation of smooth muscle cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of positive chemotaxis
localization within membrane
low-density lipoprotein particle mediated signaling
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Cadherin 13 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- AHP1018 detects a band/s of approximately 78kDa in 3T3 cell lysates.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Ivanov, D. et al. (2004) T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells.
Cardiovasc Res. 64 (1): 132-43.
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