Cadherin 13 antibody


Cadherin 13 is classified as a cell-cell adhesion molecule, although it is likely that it’s role is in signalling and not physical adhesion. It is involved in regulating low-density lipoprotein-initiated cell proliferation, keratinocyte proliferation, neural cell growth and may play a role in metabolic regulation. Cadherin 13 protects endothelial cells from oxidative stress-induced apoptosis and may contribute to progression of vascular disorders such as atherosclerosis, restenosis and tumour angiogenesis.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to Cadherin 13 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.02% Sodium Azide (NaN3) - Immunogen
- Synthetic peptide corresponding to N-terminus of human Cadherin 13.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P55290
- Entrez Gene
- CDH13
- GO Terms
- GO:0005509 calcium ion binding
- GO:0001938 positive regulation of endothelial cell proliferation
- GO:0001954 positive regulation of cell-matrix adhesion
- GO:0002040 sprouting angiogenesis
- GO:0005615 extracellular space
- GO:0005901 caveola
- GO:0007156 homophilic cell adhesion
- GO:0007162 negative regulation of cell adhesion
- GO:0007266 Rho protein signal transduction
- GO:0016339 calcium-dependent cell-cell adhesion
- GO:0008285 negative regulation of cell proliferation
- GO:0031225 anchored to membrane
- GO:0016601 Rac protein signal transduction
- GO:0030032 lamellipodium assembly
- GO:0030100 regulation of endocytosis
- GO:0030169 low-density lipoprotein particle binding
- GO:0030335 positive regulation of cell migration
- GO:0034329 cell junction assembly
- GO:0034332 adherens junction organization
- GO:0042058 regulation of epidermal growth factor receptor signaling pathway
- GO:0043005 neuron projection
- GO:0043542 endothelial cell migration
- GO:0043616 keratinocyte proliferation
- GO:0045296 cadherin binding
- GO:0045885 positive regulation of survival gene product expression
- GO:0048661 positive regulation of smooth muscle cell proliferation
- GO:0050850 positive regulation of calcium-mediated signaling
- GO:0050927 positive regulation of positive chemotaxis
- GO:0051668 localization within membrane
- GO:0055096 low-density lipoprotein particle mediated signaling
- GO:0055100 adiponectin binding
- Regulatory
- For research purposes only
Applications of Cadherin 13 antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunofluorescence | |||
Western Blotting | 0.5 | 1.0ug/ml |
- Western Blotting
- AHP1018 detects a band/s of approximately 78kDa in 3T3 cell lysates.
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | F IF WB | 0.1 mg | ||
Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | F IF WB | 0.1 mg | ||
Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | F IF WB | 0.1 mg |
Useful Reagents Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml |
Product Specific References
Further Reading
-
Ivanov, D. et al. (2004) T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells.
Cardiovasc Res. 64 (1): 132-43.
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