Cadherin 13 antibody

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Rabbit anti Human Cadherin 13

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP1018 IF WB 0.1 mg
Rabbit anti Human cadherin 13 antibody recognizes human Cadherin 13, a ~78 kDa, calcium-dependent, glycoprotein. While Cadherin 13 is a member of the cadherin family, it lacks their conserved cytoplasmic region, being instead anchored to the plasma membrane via glycosylphosphatidylinositol linkage. It is expressed in the heart and CNS with the exception of the cerebellum and spinal cord.

Cadherin 13 is classified as a cell-cell adhesion molecule, although it is likely that it’s role is in signalling and not physical adhesion. It is involved in regulating low-density lipoprotein-initiated cell proliferation, keratinocyte proliferation, neural cell growth and may play a role in metabolic regulation. Cadherin 13 protects endothelial cells from oxidative stress-induced apoptosis and may contribute to progression of vascular disorders such as atherosclerosis, restenosis and tumour angiogenesis.

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to Cadherin 13 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide (NaN3)
Immunogen
Synthetic peptide corresponding to N-terminus of human Cadherin 13.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P55290 Related reagents
Entrez Gene
CDH13 Related reagents
GO Terms
GO:0005509 calcium ion binding
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002040 sprouting angiogenesis
GO:0005615 extracellular space
GO:0005901 caveola
GO:0007156 homophilic cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007266 Rho protein signal transduction
GO:0016339 calcium-dependent cell-cell adhesion
GO:0008285 negative regulation of cell proliferation
GO:0031225 anchored to membrane
GO:0016601 Rac protein signal transduction
GO:0030032 lamellipodium assembly
GO:0030100 regulation of endocytosis
GO:0030169 low-density lipoprotein particle binding
GO:0030335 positive regulation of cell migration
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0043005 neuron projection
GO:0043542 endothelial cell migration
GO:0043616 keratinocyte proliferation
GO:0045296 cadherin binding
GO:0045885 positive regulation of survival gene product expression
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050927 positive regulation of positive chemotaxis
GO:0051668 localization within membrane
GO:0055096 low-density lipoprotein particle mediated signaling
GO:0055100 adiponectin binding
Regulatory
For research purposes only

Applications of Cadherin 13 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence
Western Blotting 0.5 1.0ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1018 detects a band/s of approximately 78kDa in 3T3 cell lysates.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB

Useful Reagents Available

Description Product Code Pack Size Applications List Price Quantity
TidyBlot™ Western Blot Detection Reagent:HRP STAR209P 0.5 ml WB*

Product Specific References

Further Reading

  1. Ivanov, D. (2004) T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells.
    Cardiovasc Res. 64:132-143.