Cadherin 13 antibody
Rabbit anti Human cadherin 13 antibody recognizes human Cadherin 13, a ~78 kDa, calcium-dependent, glycoprotein. While Cadherin 13 is a member of the cadherin family, it lacks their conserved cytoplasmic region, being instead anchored to the plasma membrane via glycosylphosphatidylinositol linkage. It is expressed in the heart and CNS with the exception of the cerebellum and spinal cord.
Cadherin 13 is classified as a cell-cell adhesion molecule, although it is likely that it’s role is in signalling and not physical adhesion. It is involved in regulating low-density lipoprotein-initiated cell proliferation, keratinocyte proliferation, neural cell growth and may play a role in metabolic regulation. Cadherin 13 protects endothelial cells from oxidative stress-induced apoptosis and may contribute to progression of vascular disorders such as atherosclerosis, restenosis and tumour angiogenesis.
Cadherin 13 is classified as a cell-cell adhesion molecule, although it is likely that it’s role is in signalling and not physical adhesion. It is involved in regulating low-density lipoprotein-initiated cell proliferation, keratinocyte proliferation, neural cell growth and may play a role in metabolic regulation. Cadherin 13 protects endothelial cells from oxidative stress-induced apoptosis and may contribute to progression of vascular disorders such as atherosclerosis, restenosis and tumour angiogenesis.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to Cadherin 13 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.02% Sodium Azide (NaN3) - Immunogen
- Synthetic peptide corresponding to N-terminus of human Cadherin 13.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P55290
- Entrez Gene
- CDH13
- GO Terms
- GO:0005509 calcium ion binding
- GO:0001938 positive regulation of endothelial cell proliferation
- GO:0001954 positive regulation of cell-matrix adhesion
- GO:0002040 sprouting angiogenesis
- GO:0005615 extracellular space
- GO:0005901 caveola
- GO:0007156 homophilic cell adhesion
- GO:0007162 negative regulation of cell adhesion
- GO:0007266 Rho protein signal transduction
- GO:0016339 calcium-dependent cell-cell adhesion
- GO:0008285 negative regulation of cell proliferation
- GO:0031225 anchored to membrane
- GO:0016601 Rac protein signal transduction
- GO:0030032 lamellipodium assembly
- GO:0030100 regulation of endocytosis
- GO:0030169 low-density lipoprotein particle binding
- GO:0030335 positive regulation of cell migration
- GO:0034329 cell junction assembly
- GO:0034332 adherens junction organization
- GO:0042058 regulation of epidermal growth factor receptor signaling pathway
- GO:0043005 neuron projection
- GO:0043542 endothelial cell migration
- GO:0043616 keratinocyte proliferation
- GO:0045296 cadherin binding
- GO:0045885 positive regulation of survival gene product expression
- GO:0048661 positive regulation of smooth muscle cell proliferation
- GO:0050850 positive regulation of calcium-mediated signaling
- GO:0050927 positive regulation of positive chemotaxis
- GO:0051668 localization within membrane
- GO:0055096 low-density lipoprotein particle mediated signaling
- GO:0055100 adiponectin binding
- Regulatory
- For research purposes only
Applications of Cadherin 13 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunofluorescence | |||
| Western Blotting | 0.5 | 1.0ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- AHP1018 detects a band/s of approximately 78kDa in 3T3 cell lysates.
Copyright © 2020 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
|
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| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
|
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| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
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| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
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| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
|
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| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
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| Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | F IF WB | 0.1 mg | ||
| Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | F IF WB | 0.1 mg | ||
| Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | F IF WB | 0.1 mg |
Useful Reagents Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml |
Product Specific References
Further Reading
-
Ivanov, D. et al. (2004) T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells.
Cardiovasc Res. 64 (1): 132-43.
