c-Myc (pThr358) antibody

Rabbit anti c-Myc (pThr358)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
c-Myc (pThr358)

Product Code Applications Pack Size List Price Your Price Qty
AHP2583
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SDS Safety Datasheet SDS
WB 50 µl loader
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Rabbit anti c-Myc (pThr358) antibody recognizes proto-oncogene c-Myc, also known as Class E basic helix-loop-helix protein 39, transcription factor p64 and avian myelocytomatosis viral oncogene homolog, when phosphorylated at threonine 358. c-Myc is a transcription factor and a member of the Myc family of basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors. c-Myc is involved in regulation of the cell cycle, cell differentiation and apoptosis.

c-Myc is phosphorylated at threonine 358 by PAK2, this negatively regulates c-Myc activity by inhibiting DNA binding (Huang et al. 2004).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to c-Myc (pThr358) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Phospho specific-peptide corresponding to residues surrounding threonine 358 of human c-Myc
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Further Reading

  1. Huang, Z. et al. (2004) Negative control of the Myc protein by the stress-responsive kinase Pak2.
    Mol Cell Biol. 24 (4): 1582-94.

UniProt
P01106
Entrez Gene
MYC
GO Terms
GO:0005515 protein binding
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006879 cellular iron ion homeostasis
GO:0007050 cell cycle arrest
GO:0008283 cell proliferation
GO:0042493 response to drug
GO:0016563 transcription activator activity
GO:0032204 regulation of telomere maintenance
GO:0070888 E-box binding
GO:0090096 positive regulation of metanephric cap mesenchymal cell proliferation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products