Rabbit anti C-IAP1 antibody recognizes cellular inhibitor of apoptosis 1 (C-IAP1), also known as baculoviral IAP repeat-containing protein 2 or inhibitor of apoptosis protein 2. C-IAP1 is a member of the inhibitor of apoptosis protein (IAP) family and is involved in the regulation of apoptosis and caspases. C-IAP1 also functions as an E3 ubiquitin-protein ligase and plays a role in innate immune signaling.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to C-IAP1 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Recombinant human C-IAP1
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
ubiquitin-protein ligase activity
cellular component disassembly involved in apoptosis
cell surface receptor linked signaling pathway
zinc ion binding
internal side of plasma membrane
CD40 receptor complex
positive regulation of I-kappaB kinase/NF-kappaB cascade
proteasomal ubiquitin-dependent protein catabolic process
protein N-terminus binding
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of C-IAP1 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti C-IAP1 antibody detects a band of approximately 70 kDa in cell lysates under reducing conditions
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Secondary Antibodies Available
Useful Reagents Available