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c-Fos antibody

Rabbit anti c-Fos

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
c-Fos

Product Code Applications Pack Size List Price Your Price Qty
AHP2411
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 mg loader
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loader

Rabbit anti c-Fos antibody recognizes c-Fos also known as G0/G1 switch regulatory protein 7 (G0S7). The c-Fos transcription factor is encoded by the c-Fos proto-oncogene and dimerizes with c-Jun, JDP and ATF family members to form the AP-1 transcription factor (Eferl and Wagner 2003).

c-Fos plays an essential role in mediating cellular signaling responses after cellular stress. The ability of the c-Fos protein to act as a transcription factor is regulated by phosphorylation on selected sites by the kinases p38, ERK, RSK1 and RSK2 (Lopez-Bergami et al. 2011). The protein accumulates in the nucleus, where it acts as a transcription factor upon formation of heterodimers with c-Jun. This binding prevents the nuclear export and subsequent proteosomal degradation of c-Fos (Halazonetiset al. 1988).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography
Antiserum Preparation
Antiserum to c-Fos was raised by repeated immunisation of rabbits with highly purified antigen
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.1% Sodium Azide (NaN3)
0.2% Gelatin
Immunogen
Peptide mapping to the amino terminus of human c-Fos
Approx. Protein Concentrations
IgG concentration 0.2 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/200
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti c-Fos recognizes a band of approximately 55 kDa when run under reducing conditions

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UniProt
P01100
Entrez Gene
FOS
GO Terms
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003704 specific RNA polymerase II transcription factor activity
GO:0006306 DNA methylation
GO:0006954 inflammatory response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008063 Toll signaling pathway
GO:0010843 promoter binding
GO:0034130 toll-like receptor 1 signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034614 cellular response to reactive oxygen species
GO:0045087 innate immune response
GO:0051090 regulation of transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0060395 SMAD protein signal transduction
GO:0070412 R-SMAD binding

AHP2411

180613

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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