C-ABL antibody


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WB P ResetRabbit anti C-ABL
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- C-ABL
Rabbit anti C-ABL antibody recognizes tyrosine-protein kinase, also known as ABL1 and JTK7. It was first identified as an oncogene associated with chromosome translocations in human leukemias (Greuber at al. 2013). It regulates cell growth and survival, oxidative stress, DNA-damage responses and cell migration (Hantschel and Superti-Furga 2004). C-ABL plays role in the cellular response to growth factors (Plattner et al. 1999). It phosphorylates EGF R and regulates receptor endocytosis (Tanos and Pendergast 2006). Enhanced C-ABL expression and activation has been detected in solid tumors (Greuber et al. 2013). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to C-ABL was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- A synthetic peptide corresponding to amino acids 533-545 of human C-ABL
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin | ![]() |
1/100 | 1/200 |
Western Blotting | ![]() |
1/500 | 1/2000 |
- Western Blotting
- Rabbit anti C-ABL antibody detects a band of approximately 139 kDa in HeLa cell lysate under reducing conditions
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | TidyBlot Western Blot Detection Reagent:HRP |
- UniProt
- P00519
- Entrez Gene
- ABL1
- GO Terms
- GO:0000115 regulation of transcription involved in S phase of mitotic cell cycle
- GO:0000287 magnesium ion binding
- GO:0003677 DNA binding
- GO:0030036 actin cytoskeleton organization
- GO:0007596 blood coagulation
- GO:0007155 cell adhesion
- GO:0005829 cytosol
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0051019 mitogen-activated protein kinase binding
- View More GO Terms
- GO:0005524 ATP binding
- GO:0005730 nucleolus
- GO:0005856 cytoskeleton
- GO:0006298 mismatch repair
- GO:0007411 axon guidance
- GO:0008022 protein C-terminus binding
- GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis
- GO:0017124 SH3 domain binding
- GO:0018108 peptidyl-tyrosine phosphorylation
- GO:0030145 manganese ion binding
- GO:0031965 nuclear membrane
- GO:0042692 muscle cell differentiation
- GO:0048471 perinuclear region of cytoplasm
- GO:0051149 positive regulation of muscle cell differentiation
- GO:0051353 positive regulation of oxidoreductase activity
- GO:0070064 proline-rich region binding
- GO:0071901 negative regulation of protein serine/threonine kinase activity
AHP2718

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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