BMP-7 antibody

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P ResetRabbit anti Human BMP-7
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- BMP-7
Rabbit anti Human BMP-7 antibody recognizes the disulphide-linked homodimeric cysteine knot protein known as human Bone Morphogenetic Protein 7 (BMP-7) or Osteogenic protein 1 (OP-1). BMP-7 is a member of the transforming growth factor beta (TGF-B) superfamily and one of a number of osteogenic proteins shown to induce bone and cartilage formation, and to play an important role in developmental processes, including cell proliferation, differentiation, apoptosis and morphogenesis. BMPs act through binding with a receptor complex consisting of type I and type II serine/threonine kinases, resulting ultimately in the activation of the Smad protein and mitogen-activated protein kinase (MAPK) signaling pathways. Several antagonist proteins, including, noggin, chordin, gremlin and follistatin, are responsible for modulating the signaling effects of BMPs, through the binding and blocking of receptor ligands, thereby preventing activation. BMP-7 is involved during ontogeny of the kidney with prominent expression in renal tubules. Experimental diabetic nephropathy indicates BMP-7 has antifibrogenic properties and appears to act as an antagonist to TGF-Beta (Wang et al. 2001 & Godin et al. 1998). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human BMP-7 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- Recombinant human BMP-7.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
0.5ug/ml | |
Immunohistology - Paraffin 1 | ![]() |
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Western Blotting | ![]() |
0.1 | 0.2ug/ml |
- 1 This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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Description | Sheep anti Rabbit IgG:RPE | ||||||
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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Description | Sheep anti Rabbit IgG:FITC | ||||||
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):HRP |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Antigen Retrieval Buffer, pH8.0 | BUF025A | P | 500 ml | Log in | |||
List Price | Your Price | ||||||
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Description | Antigen Retrieval Buffer, pH8.0 |
References for BMP-7 antibody
-
Delpech, P.O. et al. (2014) Effects of warm ischaemia combined with cold preservation on the hypoxia-inducible factor 1α pathway in an experimental renal autotransplantation model.
Br J Surg. 101 (13): 1739-50.
Further Reading
-
Trousse, F. et al. (2001) Bmp4 mediates apoptotic cell death in the developing chick eye.
J Neurosci. 21 (4): 1292-301. -
Balemans, W. & Van Hul, W. (2002) Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators.
Dev Biol. 250 (2): 231-50. -
Sebald, W. et al. (2004) Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction.
Biol Chem. 385 (8): 697-710. -
Wang, S.N. et al. (2001) Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy.
J Am Soc Nephrol. 12 (11): 2392-9. -
Godin, R.E. et al. (1998) Regulation of BMP7 expression during kidney development.
Development. 125 (17): 3473-82.
- Synonyms
- OP-1
- RRID
- AB_566393
- UniProt
- P18075
- Entrez Gene
- BMP7
- GO Terms
- GO:0001503 ossification
- GO:0001657 ureteric bud development
- GO:0001823 mesonephros development
- GO:0001837 epithelial to mesenchymal transition
- GO:0005125 cytokine activity
- GO:0005615 extracellular space
- GO:0040007 growth
- GO:0008083 growth factor activity
- GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
- View More GO Terms
- GO:0030501 positive regulation of bone mineralization
- GO:0030509 BMP signaling pathway
- GO:0032582 negative regulation of gene-specific transcription
- GO:0034504 protein localization to nucleus
- GO:0042326 negative regulation of phosphorylation
- GO:0043401 steroid hormone mediated signaling pathway
- GO:0043407 negative regulation of MAP kinase activity
- GO:0045669 positive regulation of osteoblast differentiation
- GO:0045839 negative regulation of mitosis
- GO:0051216 cartilage development
- GO:0060389 pathway-restricted SMAD protein phosphorylation
- GO:0060395 SMAD protein signal transduction
- GO:0072125 negative regulation of glomerular mesangial cell proliferation
AHP961

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