BMP-6 antibody

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Rabbit anti BMP-6

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00257
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human BMP-6 antibody recognizes BMP-6, also known as bone morphogenetic protein 6, VG-1-related protein, VGR-1, vegetal related growth factor (TGFB-related) and vegetal-related (TGFB related) cytokine.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by the ability of a demineralized bone extract to induce endochondral osteogenesis in vivo at an extraskeletal site. Based on its expression early in embryogenesis, the protein encoded by the BMP6 gene has a proposed role in early development. In addition, the fact that BMP-6 is closely related to BMP-5 and BMP-7 has led to speculation of possible bone inductive activity (provided by RefSeq, Jul 2008).

Rabbit anti Human BMP-6 antibody detects a band of 55-65 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti BMP-6 detects a band of approximately 55-65 kDa in human placental tissue
Product Form
Ig fraction - liquid
Preparation
Rabbit Ig fraction prepared by ammonium sulphate precipitation
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 25-55 of human BMP-6

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
P22004
Entrez Gene
BMP6
GO Terms
GO:0005125 cytokine activity
GO:0005615 extracellular space
GO:0006955 immune response
GO:0040007 growth
GO:0008083 growth factor activity
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0032349 positive regulation of aldosterone biosynthetic process
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046982 protein heterodimerization activity
GO:0051216 cartilage development
GO:0060395 SMAD protein signal transduction
GO:0070700 BMP receptor binding
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory
For research purposes only

Applications of BMP-6 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml