BMP-4 antibody
Rabbit anti Human BMP-4 antibody recognizes bone morphogenetic protein 4 (BMP-4) also known as bone morphogenetic protein 2B (BMP-2B).
BMP-4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo at an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of the BMP-4 gene sequence has been described and three variants reported, all encoding an identical protein (provided by RefSeq, Jul 2008).
Rabbit anti Human BMP-4 antibody detects a band of 47 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
BMP-4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo at an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of the BMP-4 gene sequence has been described and three variants reported, all encoding an identical protein (provided by RefSeq, Jul 2008).
Rabbit anti Human BMP-4 antibody detects a band of 47 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti BMP-4 detects a band of approximately 47 kDa in A549 cell lysate
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose - Immunogen
- Synthetic peptide corresponding to the C-terminal region of human BMP-4
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P12644
- Entrez Gene
- BMP4
- GO Terms
- GO:0000186 activation of MAPKK activity
- GO:0001649 osteoblast differentiation
- GO:0001658 branching involved in ureteric bud morphogenesis
- GO:0001823 mesonephros development
- GO:0001938 positive regulation of endothelial cell proliferation
- GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
- GO:0002320 lymphoid progenitor cell differentiation
- GO:0003197 endocardial cushion development
- GO:0003279 cardiac septum development
- GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
- GO:0005125 cytokine activity
- GO:0005578 proteinaceous extracellular matrix
- GO:0005615 extracellular space
- GO:0008083 growth factor activity
- GO:0009791 post-embryonic development
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010595 positive regulation of endothelial cell migration
- GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
- GO:0016563 transcription activator activity
- GO:0016564 transcription repressor activity
- GO:0030501 positive regulation of bone mineralization
- GO:0032967 positive regulation of collagen biosynthetic process
- GO:0033088 negative regulation of immature T cell proliferation in thymus
- GO:0034504 protein localization to nucleus
- GO:0042056 chemoattractant activity
- GO:0042326 negative regulation of phosphorylation
- GO:0043065 positive regulation of apoptosis
- GO:0043401 steroid hormone mediated signaling pathway
- GO:0043407 negative regulation of MAP kinase activity
- GO:0045662 negative regulation of myoblast differentiation
- GO:0045669 positive regulation of osteoblast differentiation
- GO:0045839 negative regulation of mitosis
- GO:0045843 negative regulation of striated muscle tissue development
- GO:0048286 lung alveolus development
- GO:0048392 intermediate mesodermal cell differentiation
- GO:0048661 positive regulation of smooth muscle cell proliferation
- GO:0051216 cartilage development
- GO:0060391 positive regulation of SMAD protein import into nucleus
- GO:0060395 SMAD protein signal transduction
- GO:0060433 bronchus development
- GO:0060502 epithelial cell proliferation involved in lung morphogenesis
- GO:0060503 bud dilation involved in lung branching
- GO:0061036 positive regulation of cartilage development
- GO:0061155 pulmonary artery endothelial tube morphogenesis
- GO:0070244 negative regulation of thymocyte apoptosis
- GO:0070700 BMP receptor binding
- GO:0071893 BMP signaling pathway involved in nephric duct formation
- GO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
- GO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
- GO:0072125 negative regulation of glomerular mesangial cell proliferation
- GO:0090184 positive regulation of kidney development
- GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis
- GO:0090194 negative regulation of glomerulus development
- GO:2000005 negative regulation of metanephric S-shaped body morphogenesis
- GO:2000007 negative regulation of metanephric comma-shaped body morphogenesis
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of BMP-4 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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