Beta Amyloid antibody
Rabbit anti Human beta amyloid antibody (AHP676) used to evaluate amyloid β expression i mouse lysated by western blotting.
Image caption:
p53 counteracts WWOX-mediated suppression of NCI-H1299 cell growth in nude mice and this antagonism leads to neurodegeneraiton in vivo. a NCI-H1299 cells were transiently overexpressed with p53-DsRed and/or WWOX-ECFP, or EGFP only. Nude mice received subcutaneous injections of these cells twice on both sides of the flanks. Tumor sizes were measured daily. WWOX suppressed tumor growth, and the suppression was abolished by p53. A representative data is shown from two experiments. b Mice were sacrificed on day 86. Spleen enlargement occurred in all mice except in the mouse harboring WWOX-expressing NCI-H1299. c Protein aggregates were found for pERK, BACE, APP, Aβ, NFT and α-tubulin in the brain of mouse inoculated with p53/WWOX-expressing NCI-H1299 (top panel; nonreducing gels). APP was degraded. Under reducing conditions (bottom panel), aggregation of BECN-1, neurofilament NF-M/H, and AIF is shown. d Similar results were observed for the expression of BACE, APP, Aβ, BECN-1, and αSynuclein in the mouse lung
From: Chou PY, Lin SR, Lee MH, Schultz L, Sze CI, Chang NS.
A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism.
Cell Commun Signal. 2019 Jul 17;17(1):76.
doi: 10.1186/s12964-019-0382-y.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Filter by Application:
WB ResetRabbit anti Human Beta Amyloid (aa1-40)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Beta Amyloid
- Region
- (aa1-40)
Antibody Quality and 
Unrivaled 
| Rabbit anti Human beta amyloid antibody recognises the beta amyloid (1-40) peptide that is thought to be the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, a muscle disease. Beta amyloid also forms aggregates coating cerebral blood vessels in cerebral amyloid angiopathy. Rabbit anti Human Beta Amyloid Antibody may be used in immunohistochemical staining of Alzheimer's disease plaques. |
- Target Species
- Human
- Product Form
- Serum - liquid
- Antiserum Preparation
- Antisera to Beta amyloid (1-40) were raised by repeated immunisations of rabbits with highly purified antigen.
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Immunohistology - Paraffin 1 | |
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| Western Blotting | |
1/500 | 1/1000 |
- 1This product requires formic acid pre-treatment of paraffin sections.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Alzheimer's disease brain
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References for Beta Amyloid antibody
-
Bertrand, E. et al. (2008) Amyloid angiopathy in idiopathic Parkinson's disease. Immunohistochemical and ultrastructural study.
Folia Neuropathol. 46 (4): 255-70. -
Jeffrey, M. et al. (2015) Membrane pathology and microglial activation of mice expressing membrane anchored or membrane released forms of Aβ and mutated human Alzheimer's precursor protein (APP).
Neuropathol Appl Neurobiol. 41 (4): 458-70. -
Jeffrey, M. et al. (2015) A Naturally Occurring Bovine Tauopathy Is Geographically Widespread in the UK.
PLoS One. 10 (6): e0129499. -
Chou, P.Y. et al. (2019) A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism.
Cell Commun Signal. 17 (1): 76.
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