Beta Amyloid antibody

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Rabbit anti Beta Amyloid (N-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP1252 E P* 0.1 ml
Rabbit anti beta amyloid antibody detects the amino-terminal region of beta amyloid, an ~87 kDa member of the amyloid precursor protein family expressed in the adult brain. Beta amyloid is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer's disease (AD). Multiple transcript variants encoding several different isoforms have been found for this gene.

Mutations to the gene can also cause cerebroarterial amyloidosis (cerebral amyloid angiopathy), a condition characterized by the progressive deposition of amyloid protein in cerebral blood vessel walls leading to ischemia, hemorrhage and progressive dementia.

Product Details

Target Species
Human
Product Form
Serum - liquid
Antiserum Preparation
Antisera to amyloid beta (NT) were raised by repeated immunisations of rabbits with highly purified antigen.
Preservative Stabilisers
0.09%Sodium Azide (NaN3)
Immunogen
Synthetic peptide corresponding to amino acid sequence 1-14 of human Amyloid Beta protein.

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P05067 Related reagents
Entrez Gene
APP Related reagents
Regulatory
For research purposes only

Applications of Beta Amyloid antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/1000
Immunohistology - Paraffin 1 1/200
  1. 1This product requires formic acid pre-treatment of paraffin sections.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human Alzheimer disease brain.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB

Product Specific References

References for Beta Amyloid antibody

  1. Sambamurti, K. et al. (2002) Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease.
    Neuromolecular Med. 1:1-31.
  2. Finder, V. et al. (2007) Amyloid-beta aggregation.
    Neurodegener. Dis. 4:13-27.
  3. Nežić S et al. (2017) Histological and immunohistochemical characteristics of cerebral amyloid angiopathy in elderly dogs.
    Vet Q. 37 (1): 1-7.