Bcl-6 antibody

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Anti Bcl-6 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with Bcl-6 antibody followed by detection with HRP conjugated Goat anti Rabbit (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 2 second exposure. Arrow points to Bcl-6 (molecular weight 98 kDa)

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Rabbit anti Bcl-6

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: Bcl-6

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VPA00255 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human Bcl-6 antibody recognizes Bcl-6, also known as B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, B-cell lymphoma 6 protein transcript, cys-his2 zinc finger transcription factor, lymphoma-associated zinc finger gene on chromosome 3, protein LAZ-3, zinc finger and BTB domain-containing protein 27, zinc finger protein 51 and zinc finger transcription factor BCL6S.

The protein encoded by the Bcl-6 gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcriptional corepressors. Bcl-6 is found to be frequently translocated and hyper-mutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for Bcl-6 (provided by RefSeq, Jul 2008).

Rabbit anti Human Bcl-6 protein antibody detects a band of 98 kDa. This antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti Bcl-6 detects a band of approximately 98 kDa in Ramos cell lysate.
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: KLH-conjugated synthetic peptide corresponding to aa 364-395 of human Bcl-6
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Mouse

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: P41182
Entrez Gene: BCL6
GO Terms: GO:0000060 protein import into nucleus, translocation; GO:0000122 negative regulation of transcription from RNA polymerase II promoter; GO:0005515 protein binding; GO:0002634 regulation of germinal center formation; GO:0002903 negative regulation of B cell apoptosis; GO:0003700 sequence-specific DNA binding transcription factor activity; GO:0005634 nucleus; GO:0006974 response to DNA damage stimulus; GO:0008270 zinc ion binding; View More GO Terms; GO:0016564 transcription repressor activity; GO:0030308 negative regulation of cell growth; GO:0043065 positive regulation of apoptosis; GO:0043565 sequence-specific DNA binding; GO:0045749 negative regulation of S phase of mitotic cell cycle