BAP31 antibody

Rabbit anti BAP31

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
BAP31

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VPA00088
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Rabbit anti Human BAP31 antibody recognizes the human chaperone protein, B-cell receptor-associated protein 31, also known as BAP31. BAP31 is a 246 amino acid ~28 kDa conserved multi pass type III integral transmembrane protein of the endoplasmic reticulum, containing two caspase cleavage sites within its cytosolic domain.

BAP31 appears to be a multi-functional ER-associated transport protein, identified through its association with membrane IgD in B-cells (Adachi et al. 1996). Several proteins associate with BAP31, including the Beta2 integrin receptor CD11b/CD18 (Zen et al. 2004), non-muscle gamma-actin and myosin B heavy chain (Ducret et al. 2003). BAP31 associates with Bcl-2 and cleavage by initiator caspases including caspase 1 and 8 generating a membrane-integrated p20 fragment which is itself a potent inducer of apoptosis when expressed ectopically (Breckenridge et al. 2003).

Rabbit anti Human BAP31 antibody detects BAP31 as a band of approximately 24 kDa in a wide range of human cell line lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Rabbit anti BAP31 detects a band of approximately 24 kDa in Jurkat cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
17 amino acid peptide located near human BAP31 C-terminus.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Synonyms
p28
UniProt
P51572
Entrez Gene
BCAP31
GO Terms
GO:0016192 vesicle-mediated transport
GO:0005102 receptor binding
GO:0005829 cytosol
GO:0005887 integral to plasma membrane
GO:0005789 endoplasmic reticulum membrane
GO:0006886 intracellular protein transport
GO:0006921 cellular component disassembly involved in apoptosis
GO:0006955 immune response
GO:0033116 ER-Golgi intermediate compartment membrane
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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