BACE1 antibody

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Goat anti Human BACE1 (C-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP740 P* 0.1 ml
Goat anti BACE1 antibody recognizes human beta-site APP-cleaving enzyme 1, also known as beta- secretase 1, BACE1, Aspartyl protease 2, Asp2 or Memapsin-2. BACE1 is a 501 amino acid, the aminio terminal 45 residues constituting the signal and propeptide moieties, ~70 kDa aspartic protease.

BACE1 is involved in the cleavage of the amyloid precursor protein (APP) leading to the generation and extracellular release of soluble amyloid beta peptide (Lin et al. 2000). Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease (Vassar et al. 1999).

Product Details

Target Species
Human
Product Form
Serum - liquid
Antiserum Preparation
Antisera to human BACE1 (C-terminal) were raised by repeated immunisations of goats with highly purified antigen.
Preservative Stabilisers
0.09%Sodium Azide
Immunogen
Synthetic peptide CLRQQHDDFADDISLLK corresponding to the C-terminal amino sequence 458-501 of human BACE.

Storage Information

Storage
Store at +4oC or at -20oC if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P56817 Related reagents
Entrez Gene
BACE1 Related reagents
GO Terms
GO:0005515 protein binding
GO:0004190 aspartic-type endopeptidase activity
GO:0005783 endoplasmic reticulum
GO:0005887 integral to plasma membrane
GO:0005768 endosome
GO:0005802 trans-Golgi network
GO:0006509 membrane protein ectodomain proteolysis
GO:0008798 beta-aspartyl-peptidase activity
GO:0009986 cell surface
GO:0050435 beta-amyloid metabolic process
Regulatory
For research purposes only

Applications of BACE1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1 1/100 1/200
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Rabbit anti Goat IgG (Fc):FITC STAR122F 1 mg F
Rabbit anti Goat IgG (Fc):HRP STAR122P 1 mg C E WB