ASK1 (pSer83) antibody

Rabbit anti ASK1 (pSer83)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- ASK1 (pSer83)
Rabbit anti ASK1 (pSer83) antibody recognizes apoptosis signal-regulating kinase 1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) and MAPK/ERK kinase kinase 5 (MEKK 5), when phosphorylated at serine 83. ASK1 is a serine/threonine kinase that plays an important role in the apoptotic response to various stimuli including oxidative stress, cytokines (e.g. TNF) and endoplasmic reticulum stress. Akt in conjunction to Hsp90 phosphorylates ASK1 at serine 83 to inhibit ASK1 induced apoptosis. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to ASK1 (pSER83) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- KLH conjugated peptide corresponding to amino acids 76-87 of human ASK-1 protein.
- Approx. Protein Concentrations
- IgG concentration 2.0mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
1/5,000 | 1/10,000 |
Western Blotting | ![]() |
1/1,000 |
- Western Blotting
- AHP1242 detects a band of approximately 155kDa in SW1353 cell lysates.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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Description | Sheep anti Rabbit IgG:FITC | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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Description | Sheep anti Rabbit IgG:RPE |
Further Reading
-
Zhang, R. et al. (2005) Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis.
Oncogene. 24: 3954-3963. -
Hayakawa, T. et al. (2006) The ASK1-MAP kinase pathways in immune and stress responses.
Microbes Infect. 8: 1098-1107. -
Takeda, K. et al. (2003) Roles of MAPKKK ASK1 in stress-induced cell death.
Cell Struct. Funct. 28: 23-29.
- Synonyms
- Apoptosis SIGNAL-REGULATING Kinase 1
- RRID
- AB_844577
- UniProt
- Q99683
- Entrez Gene
- MAP3K5
- GO Terms
- GO:0000287 magnesium ion binding
- GO:0006915 apoptosis
- GO:0004709 MAP kinase kinase kinase activity
- GO:0005524 ATP binding
- GO:0007257 activation of JUN kinase activity
- GO:0008624 induction of apoptosis by extracellular signals
- GO:0008656 caspase activator activity
- GO:0042803 protein homodimerization activity
- GO:0044419 interspecies interaction between organisms
- View More GO Terms
AHP1242

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