Artemin antibody

Rabbit anti Human Artemin

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Artemin

Product Code Applications Pack Size List Price Your Price Qty
AHP1275
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E WB 0.1 mg loader
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loader
Search for Batch Specific Datasheets

Rabbit anti Human Artemin antibody recognizes human Artemin, a disulfide-linked homodimer and member of the GDNF (glial cell line-derived neurotrophic factor) family of ligands, and cysteine-knot superfamily of growth factors, which shares structural homology with GDNF, Persephin and Neurturin.

Artemin acts as a neurotrophic survival and differentiation factor for all peripheral ganglia, and mainly signals through binding to the GDNF-family receptor known as GFR-alpha-3, which then forms a complex with the tyrosine kinase transmembrane signalling receptor RET.

Target Species
Human
Product Form
Purified IgG - lyophilized
Reconstitution
Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended.
Antiserum Preparation
Antisera to human Artemin were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present.
Carrier Free
Yes
Immunogen
Recombinant human Artemin.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.

This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 0.5 2.0ug/ml
Western Blotting 0.1 0.2ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Further Reading

  1. Baloh, R.H. et al. (1998) Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.
    Neuron. 21: 1291-1302.
  2. Arighi, E. et al. (2005) RET tyrosine kinase signaling in development and cancer.
    Cytokine Growth Factor Rev. 16: 441-467.

Synonyms
ARTN
RRID
AB_2058559
UniProt
Q5T4W7
Entrez Gene
ARTN
GO Terms
GO:0005576 extracellular region
GO:0007165 signal transduction
GO:0007405 neuroblast proliferation
GO:0007411 axon guidance
GO:0008083 growth factor activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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