Artemin antibody
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Rabbit anti Human Artemin
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Artemin
Antibody Quality and Performance Guarantee
| Rabbit anti Human Artemin antibody recognizes human Artemin, a disulfide-linked homodimer and member of the GDNF (glial cell line-derived neurotrophic factor) family of ligands, and cysteine-knot superfamily of growth factors, which shares structural homology with GDNF, Persephin and Neurturin. Artemin acts as a neurotrophic survival and differentiation factor for all peripheral ganglia, and mainly signals through binding to the GDNF-family receptor known as GFR-alpha-3, which then forms a complex with the tyrosine kinase transmembrane signalling receptor RET. |
- Target Species
- Human
- Product Form
- Purified IgG - lyophilized
- Reconstitution
- Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended.
- Antiserum Preparation
- Antisera to human Artemin were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present.
- Carrier Free
- Yes
- Immunogen
- Recombinant human Artemin.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
0.5 | 2.0ug/ml |
| Western Blotting | |
0.1 | 0.2ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Further Reading
-
Baloh, R.H. et al. (1998) Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.
Neuron. 21: 1291-1302. -
Arighi, E. et al. (2005) RET tyrosine kinase signaling in development and cancer.
Cytokine Growth Factor Rev. 16: 441-467.
- Synonyms
- ARTN
- RRID
- AB_2058559
- UniProt
- Q5T4W7
- Entrez Gene
- ARTN
- GO Terms
- GO:0005576 extracellular region
- GO:0007165 signal transduction
- GO:0007405 neuroblast proliferation
- GO:0007411 axon guidance
- GO:0008083 growth factor activity
AHP1275
170905
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