Rabbit anti Human Artemin antibody recognizes human Artemin, a disulfide-linked homodimer and member of the GDNF (glial cell line-derived neurotrophic factor) family of ligands, and cysteine-knot superfamily of growth factors, which shares structural homology with GDNF, Persephin and Neurturin.
Artemin acts as a neurotrophic survival and differentiation factor for all peripheral ganglia, and mainly signals through binding to the GDNF-family receptor known as GFR-alpha-3, which then forms a complex with the tyrosine kinase transmembrane signalling receptor RET.
- Target Species
- Product Form
- Purified IgG - lyophilised
- Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended.
- Antiserum Preparation
- Antisera to human Artemin were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present.
- Recombinant human Artemin.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Prior to reconstitution store at +4oC.
After reconstitution store at -20oC
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of reconstitution.
- Entrez Gene
- GO Terms
growth factor activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Artemin antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Baloh, R.H. et al. (1998) Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.
Neuron. 21: 1291-1302.
Arighi, E. et al. (2005) RET tyrosine kinase signaling in development and cancer.
Cytokine Growth Factor Rev. 16: 441-467.