APOBEC3B antibody

Rabbit anti APOBEC3B

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
APOBEC3B

Product Code Applications Pack Size List Price Your Price Qty
AHP2737
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SDS Safety Datasheet SDS
WB 50 µl loader
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Rabbit anti APOBEC3B antibody recognizes DNA dC->dU-editing enzyme APOBEC3B, also known as phorbolin-1-related protein and phorbolin-2/3. It is a member of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of cytidine deaminases (Kuong and Loeb 2013). APOBEC family members function as a part of the innate immune system inhibiting retroviruses by deamination of cytosine in nascent retroviral cDNA (Harris and Liddament 2004). APOBEC3 proteins are divided into two groups: APOBEC3A, APOBEC3C, and APOBEC3H that contain one zinc-dependent cytidine deaminase domain and APOBEC3B, APOBEC3D, APOBEC3F, and APOBEC3G that contain two zinc-dependent cytidine deaminase domains (LaRue et al. 2008). APOBEC3B is overexpressed in a wide spectrum of human cancers (Zou et al. 2017).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to APOBEC3B was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human APOBEC3B
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/200 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti APOBEC3B antibody detects a band of approximately 46 kDa in HeLa, U251 and MCF7 cell lysates under reducing conditions

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UniProt
Q9UH17
Entrez Gene
APOBEC3B
GO Terms
GO:0003723 RNA binding
GO:0008270 zinc ion binding
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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