APBB1 antibody

ISO 9001 Quality Assurance Manufacturing | Print

Anti APBB1 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with APBB1 antibody followed by detection with HRP conjugated Goat anti Rabbit (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 113 second exposure. Arrow points to APBB1 (molecular weight 107 kDa)

Filter by Application:

Rabbit anti APBB1

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: APBB1

Quick Links:

Secondary Antibodies
Applications
Storage Information
Batch/Lot Specific Datasheets

Antibody Quality and Performance Guarantee

Unrivaled Technical Support

Product Code Applications Pack Size List Price Your Price Qty

List Price	Your Price
VPA00349 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
	Log in

Rabbit anti Human APBB1 antibody recognizes APBB1, also known as FE65, adaptor protein FE65a2 and amyloid beta A4 precursor protein-binding family B member 1.

The protein encoded by the APBB1 gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for APBB1 (provided by RefSeq, Mar 2012).

Rabbit anti Human APBB1 antibody detects a band of 107 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti APBB1 detects a band of approximately 107 kDa in HEK293 cell lysate.
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
2% Sucrose
Immunogen: Synthetic peptide corresponding to the N-terminal region of Human APBB1
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
List Price	Your Price
	Log in
Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: O00213
Entrez Gene: APBB1
GO Terms: GO:0005886 plasma membrane; GO:0001540 beta-amyloid binding; GO:0003682 chromatin binding; GO:0042393 histone binding; GO:0006915 apoptosis; GO:0007165 signal transduction; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0006350 transcription; View More GO Terms; GO:0006974 response to DNA damage stimulus; GO:0007050 cell cycle arrest; GO:0007409 axonogenesis; GO:0008134 transcription factor binding; GO:0016563 transcription activator activity; GO:0030027 lamellipodium; GO:0030308 negative regulation of cell growth; GO:0030426 growth cone; GO:0043065 positive regulation of apoptosis; GO:0043967 histone H4 acetylation; GO:0045202 synapse; GO:0045749 negative regulation of S phase of mitotic cell cycle; GO:0050760 negative regulation of thymidylate synthase biosynthetic process; GO:0070064 proline-rich region binding