APBB1 antibody

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Rabbit anti APBB1

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified

Product Code	Applications	Pack Size	Your Price	List Price	Quantity
VPA00349 Datasheet	WB SDS	100 µl	Log in		Get Quote

Rabbit anti Human APBB1 antibody recognizes APBB1, also known as FE65, adaptor protein FE65a2 and amyloid beta A4 precursor protein-binding family B member 1.

The protein encoded by the APBB1 gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for APBB1 (provided by RefSeq, Mar 2012).

Rabbit anti Human APBB1 antibody detects a band of 107 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species: Human
Western Blotting: Anti APBB1 detects a band of approximately 107 kDa in HEK293 cell lysate
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
2% Sucrose
Immunogen: Synthetic peptide corresponding to the N-terminal region of Human APBB1

Storage Information

Storage: Store undiluted at -20^oC, avoiding repeated freeze thaw cycles
Guarantee: 12 months from date of despatch

More Information

UniProt: O00213
Entrez Gene: APBB1
GO Terms: GO:0005886 plasma membrane; GO:0001540 beta-amyloid binding; GO:0003682 chromatin binding; GO:0042393 histone binding; GO:0006915 apoptosis; GO:0007165 signal transduction; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0006350 transcription; GO:0006974 response to DNA damage stimulus; GO:0007050 cell cycle arrest; GO:0007409 axonogenesis; GO:0008134 transcription factor binding; GO:0016563 transcription activator activity; GO:0030027 lamellipodium; GO:0030308 negative regulation of cell growth; GO:0030426 growth cone; GO:0043065 positive regulation of apoptosis; GO:0043967 histone H4 acetylation; GO:0045202 synapse; GO:0045749 negative regulation of S phase of mitotic cell cycle; GO:0050760 negative regulation of thymidylate synthase biosynthetic process; GO:0070064 proline-rich region binding
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory: For research purposes only

Applications of APBB1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description	Product Code	Applications	Pack Size	Your Price	List Price	Quantity
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in		Get Quote

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