Rabbit anti Human Annexin II antibody
recognizes human Annexin A2, also known as Annexin II (ANXA2), lipocortin 2, Chromobindin-8 or Placental anticoagulant protein IV. Annexin II isa 339 amino acid secreted protein containing 4 annexin repeats
. Annexin II is a pleiotropic calcium-dependent phospholipid-binding protein and member of the annexin family, abundantly expressed in a variety of tissues including the brain, spleen, kidney and placenta, which can exist in a monomer, heterodimer or heterotetramer form.
Annexin II acts as an autocrine factor, enhancing the formation of osteoclasts and resorption of bone, and is implicated in both exocytosis and endocytosis. Annexin II is a substrate for both tyrosine and serine/threonine kinases, and is phosphorylated following growth factor stimulation and cellular activation by viral transformation (Brambilla et al. 1991
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Annexin II antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.