Androgen Receptor antibody
Rabbit anti androgen receptor antibody recognizes androgen receptor (AR), also known as the dihydrotestosterone receptor or nuclear receptor subfamily 3 group C member 4. Androgen receptor is a member of the steroid and nuclear receptor protein family. Androgen receptor is activated upon ligand binding and functions as a transcription factor transcribing androgen responsive genes.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to androgen receptor was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Synthetic peptide corresponding to amino acids 1-100 of the human androgen receptor.
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P10275
- Entrez Gene
- AR
- GO Terms
- GO:0016049 cell growth
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0005102 receptor binding
- GO:0004882 androgen receptor activity
- GO:0005497 androgen binding
- GO:0005737 cytoplasm
- GO:0005654 nucleoplasm
- GO:0006810 transport
- GO:0007267 cell-cell signaling
- GO:0008013 beta-catenin binding
- GO:0008134 transcription factor binding
- GO:0008219 cell death
- GO:0008270 zinc ion binding
- GO:0008283 cell proliferation
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010843 promoter binding
- GO:0016563 transcription activator activity
- GO:0019899 enzyme binding
- GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
- GO:0046983 protein dimerization activity
- Regulatory
- For research purposes only
Applications of Androgen Receptor antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin | 1/50 | 1/100 | |
| Western Blotting | 1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti androgen receptor antibody detects two isoforms of androgen receptor at approximately 70 kDa and 99 kDa in 22RV-1 cell lysate and mouse tissue lysate under reducing conditions
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
|
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| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
|
|
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
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| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
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| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
|
|
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
Useful Reagents Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml |
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