Amyloid Precursor Protein antibody
Goat anti amyloid precursor protein antibody recognizes amyloid precursor protein (APP), a ~130 kDa member of the APP family, expressed in adult brain. It is a cell surface kinesin I membrane receptor which regulates the axonal transport of beta-secretase and presenilin 1.In Alzheimer's disease processing of APP by beta-secretase gives rise to amyloidogenic 42 AA beta amyloid protein that is found in senile plaques and vessels. APP binds components of the extracellular matrix such as heparin and collagen I and IV, regulating neurite growth and is also involved in neuronal adhesion, cell mobility and axonogenesis. Through it’s binding to APBB1/Tip60, APP plays a role in the regulation of transcription. APP also inhibits Notch signaling through it’s interaction with NUMB.
- Target Species
- Product Form
- Serum - liquid
- Antiserum Preparation
- Antisera to human amyloid precursor protein were raised by repeated immunisations of goats with highly purified antigen.
- Preservative Stabilisers
0.09% Sodium Azide (NaN3)
- Synthetic peptide corresponding to the amino acid sequence 44-63 of human amyloid precursor protein.
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- Shelf Life
- 18 months from date of despatch.
- P05067 Related reagents
- Entrez Gene
- APP Related reagents
- For research purposes only
Applications of Amyloid Precursor Protein antibody
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen||1/5000|
|Immunohistology - Paraffin||1/100|
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Human Alzheimer disease brain.
- Western Blotting
- AHP1253 detects a band of approximately 130kDa in neuronal cell lysates.
Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
|Description||Product Code||Pack Size||Applications||List Price||Quantity|
|Rabbit anti Goat IgG (Fc):FITC||STAR122F||1 mg||F|
|Rabbit anti Goat IgG (Fc):HRP||STAR122P||1 mg||C E WB|
Product Specific References
References for Amyloid Precursor Protein antibody
Venezia, V. (2007) Amyloid precursor protein and presenilin involvement in cell signaling.
Neurodegener. Dis. 4:101-11.