Amyloid Precursor Protein antibody

100% Secure

Goat anti Amyloid Precursor Protein (aa44-63)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP1253 C E P WB 0.1 ml
Goat anti amyloid precursor protein antibody recognizes amyloid precursor protein (APP), a ~130 kDa member of the APP family, expressed in adult brain. It is a cell surface kinesin I membrane receptor which regulates the axonal transport of beta-secretase and presenilin 1.In Alzheimer's disease processing of APP by beta-secretase gives rise to amyloidogenic 42 AA beta amyloid protein that is found in senile plaques and vessels. APP binds components of the extracellular matrix such as heparin and collagen I and IV, regulating neurite growth and is also involved in neuronal adhesion, cell mobility and axonogenesis. Through it’s binding to APBB1/Tip60, APP plays a role in the regulation of transcription. APP also inhibits Notch signaling through it’s interaction with NUMB.

Product Details

Target Species
Human
Product Form
Serum - liquid
Antiserum Preparation
Antisera to human amyloid precursor protein were raised by repeated immunisations of goats with highly purified antigen.
Preservative Stabilisers
0.09%Sodium Azide (NaN3)
Immunogen
Synthetic peptide corresponding to the amino acid sequence 44-63 of human amyloid precursor protein.

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P05067 Related reagents
Entrez Gene
APP Related reagents
Regulatory
For research purposes only

Applications of Amyloid Precursor Protein antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/1500
Immunohistology - Frozen 1/5000
Immunohistology - Paraffin 1/100
Western Blotting 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human Alzheimer disease brain.
Western Blotting
AHP1253 detects a band of approximately 130kDa in neuronal cell lysates.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Rabbit anti Goat IgG (Fc):FITC STAR122F 1 mg F
Rabbit anti Goat IgG (Fc):HRP STAR122P 1 mg C E WB

Product Specific References

References for Amyloid Precursor Protein antibody

  1. Venezia, V. (2007) Amyloid precursor protein and presenilin involvement in cell signaling.
    Neurodegener. Dis. 4:101-11.