Goat anti Human alpha synuclein antibody recognizes human alpha-synuclein.The alpha-synuclein gene, located on chromosome 4, has been linked to early onset autosomal dominant Parkinson's disease.
The protein is abundant in the nervous system, and is known to be the precursor of the non-beta amyloid component protein (NACP) of Alzheimer's disease. Alpha-synuclein has also been found to be associated with other neurodegenerative diseases such as multiple system atrophy and dementia with Lewy's bodies.
- Target Species
- Product Form
- Serum - liquid
- Antiserum Preparation
- Antisera to a-synuclein were raised by repeated immunisation of goats with highly purified antigen.
- Preservative Stabilisers
- Synthetic peptide corresponding to amino acids 116-131 of the C-terminus of a synuclein.
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Entrez Gene
- GO Terms
magnesium ion binding
calcium ion binding
positive regulation of receptor recycling
activation of caspase activity
ferrous iron binding
zinc ion binding
response to iron(II) ion
regulation of phospholipase activity
negative regulation of platelet-derived growth factor receptor signaling pathway
Hsp70 protein binding
negative regulation of microtubule polymerization
response to magnesium ion
negative regulation of transporter activity
response to lipopolysaccharide
negative regulation of monooxygenase activity
positive regulation of peptidyl-serine phosphorylation
response to interferon-gamma
negative regulation of histone acetylation
caspase inhibitor activity
negative regulation of caspase activity
positive regulation of endocytosis
negative regulation of exocytosis
tau protein binding
synaptic vesicle endocytosis
positive regulation of release of sequestered calcium ion into cytosol
negative regulation of dopamine uptake
negative regulation of serotonin uptake
negative regulation of norepinephrine uptake
positive regulation of inositol phosphate biosynthetic process
negative regulation of thrombin receptor signaling pathway
response to interleukin-1
positive regulation of protein serine/threonine kinase activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Alpha Synuclein antibody
||1/1000 vs immunising peptide
|Immunohistology - Paraffin
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
- Histology Positive Control Tissue
- Brain, Spinal Cord.
Copyright © 2019 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for Alpha Synuclein antibody
Spillantini, M.G. et al. (1997) Alpha-synuclein in Lewy bodies
Nature 388: 839-840.
Gai, W.P. et al. (1997) Multiple-system atrophy: a new alpha-synuclein disease.
Lancet 352: 547-548.