Alpha Synuclein antibody

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Goat anti Human Alpha Synuclein

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP493 E P 0.1 ml
Goat anti Human alpha synuclein antibody recognizes human alpha-synuclein.The alpha-synuclein gene, located on chromosome 4, has been linked to early onset autosomal dominant Parkinson's disease.

The protein is abundant in the nervous system, and is known to be the precursor of the non-beta amyloid component protein (NACP) of Alzheimer's disease. Alpha-synuclein has also been found to be associated with other neurodegenerative diseases such as multiple system atrophy and dementia with Lewy's bodies.

Product Details

Target Species
Human
Product Form
Serum - liquid
Antiserum Preparation
Antisera to a-synuclein were raised by repeated immunisation of goats with highly purified antigen.
Preservative Stabilisers
0.09%Sodium Azide
Immunogen
Synthetic peptide corresponding to amino acids 116-131 of the C-terminus of a synuclein.

Storage Information

Storage
Store at +4oC or at -20oC if preferred.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P37840 Related reagents
Entrez Gene
SNCA Related reagents
GO Terms
GO:0000287 magnesium ion binding
GO:0005509 calcium ion binding
GO:0001921 positive regulation of receptor recycling
GO:0042393 histone binding
GO:0005829 cytosol
GO:0005634 nucleus
GO:0005938 cell cortex
GO:0006916 anti-apoptosis
GO:0006919 activation of caspase activity
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0010040 response to iron(II) ion
GO:0010517 regulation of phospholipase activity
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0015629 actin cytoskeleton
GO:0019894 kinesin binding
GO:0030054 cell junction
GO:0030424 axon
GO:0030426 growth cone
GO:0030544 Hsp70 protein binding
GO:0031115 negative regulation of microtubule polymerization
GO:0031623 receptor internalization
GO:0032026 response to magnesium ion
GO:0032410 negative regulation of transporter activity
GO:0032496 response to lipopolysaccharide
GO:0032769 negative regulation of monooxygenase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034341 response to interferon-gamma
GO:0035067 negative regulation of histone acetylation
GO:0043014 alpha-tubulin binding
GO:0043027 caspase inhibitor activity
GO:0043154 negative regulation of caspase activity
GO:0043205 fibril
GO:0045202 synapse
GO:0045502 dynein binding
GO:0045807 positive regulation of endocytosis
GO:0045920 negative regulation of exocytosis
GO:0048156 tau protein binding
GO:0048488 synaptic vesicle endocytosis
GO:0051219 phosphoprotein binding
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051585 negative regulation of dopamine uptake
GO:0051612 negative regulation of serotonin uptake
GO:0051622 negative regulation of norepinephrine uptake
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0070495 negative regulation of thrombin receptor signaling pathway
GO:0070555 response to interleukin-1
GO:0071902 positive regulation of protein serine/threonine kinase activity
Regulatory
For research purposes only

Applications of Alpha Synuclein antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/1000 vs immunising peptide
Immunohistology - Paraffin 1/300
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Immunohistology
This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Histology Positive Control Tissue
Brain, Spinal Cord.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Rabbit anti Goat IgG (Fc):FITC STAR122F 1 mg F
Rabbit anti Goat IgG (Fc):HRP STAR122P 1 mg C E WB

Product Specific References

References for Alpha Synuclein antibody

  1. Spillantini, M.G. et al. (1997) Alpha-synuclein in Lewy bodies
    Nature 388: 839-840.
  2. Gai, W.P. et al. (1997) Multiple-system atrophy: a new alpha-synuclein disease.
    Lancet 352: 547-548.