ALK1 antibody

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Rabbit anti ALK1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00702
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human ALK1 antibody recognizes serine/threonine-protein kinase receptor R3, also known as ACVRLK1.

The ACVRL1 gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 (provided by RefSeq, Jul 2008).

Rabbit anti Human ALK1 antibody detects a band of 56 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Rabbit anti ALK1 detects a band of approximately 56 kDa in K562 cell lysates
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.01% Thimerosal
1% Bovine Serum Albumin
<50% Glycerol
Immunogen
Recombinant protein encompassing part of the C-terminal region of human ALK1

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
Guarantee
As supplied, 12 months from date of despatch.

More Information

UniProt
P37023 Related reagents
Entrez Gene
ACVRL1 Related reagents
GO Terms
GO:0001525 angiogenesis
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0005887 integral to plasma membrane
GO:0046872 metal ion binding
GO:0005524 ATP binding
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0050431 transforming growth factor beta binding
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell proliferation
GO:0009986 cell surface
GO:0010596 negative regulation of endothelial cell migration
GO:0016361 activin receptor activity, type I
GO:0030308 negative regulation of cell growth
GO:0030513 positive regulation of BMP signaling pathway
GO:0035313 wound healing, spreading of epidermal cells
GO:0045941 positive regulation of transcription
GO:0046332 SMAD binding
GO:0048185 activin binding
GO:0051895 negative regulation of focal adhesion assembly
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of ALK1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml

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