ALK1 antibody

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Anti ALK1 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with ALK1 antibody (**VPA00702**) followed by detection with HRP conjugated Goat anti Rabbit IgG (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 7 second exposure. Arrow points to ALK1 (molecular weight 56 kDa).

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Rabbit anti ALK1

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: ALK1

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VPA00702 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human ALK1 antibody recognizes serine/threonine-protein kinase receptor R3, also known as ACVRLK1.

The ACVRL1 gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 (provided by RefSeq, Jul 2008).

Rabbit anti Human ALK1 antibody detects a band of 56 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Rabbit anti ALK1 detects a band of approximately 56 kDa in K562 cell lysates.
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.01% Thimerosal
1% Bovine Serum Albumin
<50% Glycerol
Immunogen: Recombinant protein encompassing part of the C-terminal region of human ALK1
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: P37023
Entrez Gene: ACVRL1
GO Terms: GO:0001525 angiogenesis; GO:0004702 receptor signaling protein serine/threonine kinase activity; GO:0005887 integral to plasma membrane; GO:0046872 metal ion binding; GO:0005524 ATP binding; GO:0006468 protein phosphorylation; GO:0007179 transforming growth factor beta receptor signaling pathway; GO:0050431 transforming growth factor beta binding; GO:0008217 regulation of blood pressure; View More GO Terms; GO:0008285 negative regulation of cell proliferation; GO:0009986 cell surface; GO:0010596 negative regulation of endothelial cell migration; GO:0016361 activin receptor activity, type I; GO:0030308 negative regulation of cell growth; GO:0030513 positive regulation of BMP signaling pathway; GO:0035313 wound healing, spreading of epidermal cells; GO:0045941 positive regulation of transcription; GO:0046332 SMAD binding; GO:0048185 activin binding; GO:0051895 negative regulation of focal adhesion assembly