Rabbit anti AKT3 antibody recognises RAC-gamma serine/threonine-protein kinase, also known as PKB gamma, RAC-gamma, and STK-2.
It plays a critical role in the AKT signalling pathway, and belongs to the AGC subfamily of protein kinases. AKT3 is involved in metabolism, cell survival, angiogenesis, and tumor formation (Baselga and Scaltriti. 2016). It is stimulated by insulin (Barthel et al. 1998), PDGF, and IGF1 (Sandirasegarane and Kester. 2001). AKT3 is a critical regulator of the growth of triple negative breast cancers (Chin et al. 2014).
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to AKT3 was raised by repeated immunization of rabbits with highly purified antigen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Recombinant fusion protein containing a sequence corresponding to amino acids 93-154 of human AKT3 (NP_859029.1)
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
protein serine/threonine kinase activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of AKT3 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available