Goat anti Human AdipoR2 antibody recognizes an epitope within the N-terminal (NT) region of Adiponectin Receptor protein 2 (AdipoR2), a transmembrane protein and member of the ADIPOR family, expressed mainly in the liver and skeletal muscle, which acts a receptor for both globular and full-length adiponectin.
AdipoR2 acts as a mediator of fatty acid oxidation, glucose uptake by adiponectin and increased AMPK, PPARalpha ligand activity, thereby playing an important role in the regulation of glucose and lipid metabolism, and in oxidative stress.
Goat anti Human AdipoR2 is reported as suitable for use in immunocytochemistry on acetone fixed cells.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human AdipoR2 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
- Synthetic peptide CSRTPEPDIRLRKGHQLDGTRRGDNDSHQG corresponding to amino acids 11-40 within the N-terminal region of human AdipoR2.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to membrane
hormone-mediated signaling pathway
fatty acid oxidation
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Adipor2 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Liver and muscle
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
References for Adipor2 antibody
Shen, X. et al. (2012) Pioglitazone prevents hyperglycemia induced decrease of AdipoR1 and AdipoR2 in coronary arteries and coronary VSMCs.
Mol Cell Endocrinol. 363 (1-2): 27-35.
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