Adipor1 antibody
Goat anti ADIPOR1 antibody recognizes human Adiponectin receptor protein 1, also known as ADIPOR1 or Adiponectin receptor protein 1. ADIPOR1 is a 375 amino acid ㅣ kDa multipass transmembrane protein and receptor for adiponectin (UniProt: Q96A54).
Goat anti ADIPOR1 antibody recognizes an epitope within the N-terminal (NT) region of Adiponectin Receptor protein 1 . AdipoR1 is implicated in metabolic pathways, mediating increased fatty acid oxidation and glucose uptake by adiponectin. The expression of AdipoR1 in adipose tissue is decreased in obese humans, whilst weight loss results in increased expression.
Goat anti ADIPOR1 antibody is reported as suitable for use in immunocytochemistry of acetone fixed cells.
Goat anti ADIPOR1 antibody recognizes an epitope within the N-terminal (NT) region of Adiponectin Receptor protein 1 . AdipoR1 is implicated in metabolic pathways, mediating increased fatty acid oxidation and glucose uptake by adiponectin. The expression of AdipoR1 in adipose tissue is decreased in obese humans, whilst weight loss results in increased expression.
Goat anti ADIPOR1 antibody is reported as suitable for use in immunocytochemistry of acetone fixed cells.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Broad Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to AdipoR1 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin. - Immunogen
- Synthetic peptide SSHKGSVVAQGNGAPASNREADTVE corresponding to amino acids 2-26 within the N-terminal region of AdipoR1.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
Storage Information
- Storage
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q96A54
- Entrez Gene
- ADIPOR1
- GO Terms
- GO:0005886 plasma membrane
- GO:0016021 integral to membrane
- GO:0004872 receptor activity
- GO:0009755 hormone-mediated signaling pathway
- GO:0019395 fatty acid oxidation
- GO:0019901 protein kinase binding
- GO:0042562 hormone binding
- Regulatory
- For research purposes only
Applications of Adipor1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin | 1/250 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Liver and muscle
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Rabbit anti Goat IgG (Fc):FITC | STAR122F | F | 1 mg |
|
|
| Rabbit anti Goat IgG (Fc):HRP | STAR122P | C E WB | 1 mg |
|
Useful Reagents Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Antigen Retrieval Buffer, pH8.0 | BUF025A | P | 500 ml | ||
| 100x Antigen Retrieval Buffer, pH8.0 | BUF025C | P | 50 ml |
Product Specific References
References for Adipor1 antibody
-
Shen X et al. (2012) Pioglitazone prevents hyperglycemia induced decrease of AdipoR1 and AdipoR2 in coronary arteries and coronary VSMCs.
Mol Cell Endocrinol. 363 (1-2): 27-35.
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