ACVR2B antibody
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WB ResetRabbit anti ACVR2B
- Product Type
- PrecisionAb Polyclonal
- Isotype
- Polyclonal IgG
- Format
- Purified
- Specificity
- ACVR2B
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| Rabbit anti Human ACVR2B antibody recognizes activin receptor type-2B. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor (provided by RefSeq, Jul 2008). Rabbit anti Human ACVR2B antibody detects a band of 58 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
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- Target Species
- Human
- Western Blotting
- Anti ACVR2B antibody recognizes a band of approximately 58 kDa in HeLa cell lysates.
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography on immunogen.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose - Immunogen
- Synthetic peptide directed towards the C terminal region of human ACVR2B
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml | Log in | |||
| List Price | Your Price | ||||||
| Log in | |||||||
| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
- UniProt
- Q13705
- Entrez Gene
- ACVR2B
- GO Terms
- GO:0004702 receptor signaling protein serine/threonine kinase activity
- GO:0019838 growth factor binding
- GO:0005887 integral to plasma membrane
- GO:0046872 metal ion binding
- GO:0005524 ATP binding
- GO:0005737 cytoplasm
- GO:0006468 protein phosphorylation
- GO:0009952 anterior/posterior pattern formation
- GO:0009986 cell surface
- View More GO Terms
- GO:0017002 activin receptor activity
- GO:0030501 positive regulation of bone mineralization
- GO:0030509 BMP signaling pathway
- GO:0032924 activin receptor signaling pathway
- GO:0032927 positive regulation of activin receptor signaling pathway
- GO:0045449 regulation of transcription
- GO:0045669 positive regulation of osteoblast differentiation
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