ABCC4 antibody

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Goat anti ABCC4

ABCC4 antibody recognizes multidrug resistance-associated protein 4, also known as ATP-binding cassette sub-family C member 4, MRP/cMOAT-related ABC transporter, multi-specific organic anion transporter B or MOAT-B. The antibody has been validated for western blotting using whole cell lysates.

ABCC4 Antibody with Control Lysate

ABCC4 antibody recognizes multidrug resistance-associated protein 4, also known as ATP-binding cassette sub-family C member 4, MRP/cMOAT-related ABC transporter, multi-specific organic anion transporter B or MOAT-B. The antibody has been extensively validated for western blotting.

Product Type
PrecisionAb™ Polyclonal
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
VPA00068 WB 100 µl
VPA00068KT WB 2 Westerns
With Lysate 400µg
Goat anti Human ABCC4 antibody recognizes ABCC4 a 200 kDa protein and a member of the MRP family of transporters.

The ABCC4 protein shows a broad pattern of expression having been detected in the kidneys, liver, erythrocytes, adrenal glands, platelets, brain, and pancreas. ABCC4 is present in the apical membrane as well as in the basolateral membrane and is capable of transporting a broad number of substrates, including bile salt conjugates, conjugated steroids, cyclic nucleotides, nucleoside analogs, eicosanoids, and cardiovascular drugs. Although ABCC4 is present in many human drug-resistant cancer cell lines, it remains to be determined if ABCC4 is associated with resistance to drugs in solid tumors (Borst et al. 2007).

Goat anti Human ABCC4 antibody detects ABCC4 as a band of 200 kDa in a range of human cell line lysates.

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Product Form
Purified IgG - liquid
Preparation
Goat polyclonal antibody purified by affinity chromatography
Preparation
20μl Goat polyclonal antibody purified by affinity chromatography
Buffer Solution
TRIS buffered saline
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin
Immunogen
Synthetic peptide with CNGQPSTLTIFETAL from the C terminus of the protein sequence.

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
Storage
Antibody: Store undiluted at -20oC, avoiding repeated freeze thaw cycles.

Lysate: Store lyophilized lysate at -20°C. After reconstitution aliquot and store at -20°C for up to 3 months or at -80°C for longer term storage.
Shelf Life
As supplied, 12 months from date of despatch.
Shelf Life
As supplied, 12 months from date of despatch.

More Information

UniProt
O15439 Related reagents
Entrez Gene
ABCC4 Related reagents
GO Terms
GO:0005886 plasma membrane
GO:0002576 platelet degranulation
GO:0016021 integral to membrane
GO:0005254 chloride channel activity
GO:0005524 ATP binding
GO:0005624 membrane fraction
GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0030168 platelet activation
GO:0031088 platelet dense granule membrane
Acknowledgements
PrecisionAb™ is a trademark of Bio-Rad Laboratories.
Acknowledgements
PrecisionAb™ is a trademark of Bio-Rad Laboratories.
Regulatory
For research purposes only

Applications of ABCC4 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
Western Blotting 1/1000

PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.

PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.
Western Blotting
Goat anti ABCC4 detects a band of approximately 200 kDa in K562 cell lysates.
Western Blotting
Goat anti ABCC4 detects a band of approximately 200 kDa in K562 cell lysates.
Instructions For Use
Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.
Instructions For Use
Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Donkey anti Sheep/Goat IgG:HRP STAR88P 1 ml C E P WB
Donkey anti Sheep/Goat IgG:HRP STAR88P 1 ml C E P WB