5-HT7 Receptor antibody

Rabbit anti Human 5-HT7 Receptor (N-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
5-HT7 Receptor
Region
(N-TERMINAL)

Product Code Applications Pack Size List Price Your Price Qty
AHP1344
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Rabbit anti Human 5-HT& receptor antibody recognizes the N-terminal region of the serotonin (5-hydroxytryptamine, 5-HT) receptor 5-HT7, which belongs to the G-protein coupled receptor superfamily. Serotonin is a neurotransmitter and vasoactive amine which is thought to play a role in various cognitive and behavioural functions including pain, appetite, mood and sleep.

Signalling through 5-HT7 has several effects, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and gastrointestinal tract. Signalling though 5-HT7 has also been shown to contribute to early T-cell activation.

5-HT7 has been implicated in depression, autism, and other neuropsychiatric disorders.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to 5-HT7 receptor (NT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
Synthetic peptide corresponding to the N-terminal domain of human 5-HT7 receptor, conjugated to Keyhole Limpet Hemocyanin (KLH).
Approx. Protein Concentrations
IgG concentration 0.5mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1 10ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Brain, cortex.

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References for 5-HT7 Receptor antibody

  1. León-ponte, M. et al. (2007) Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor.
    Blood. 109 (8): 3139-46.
  2. Soll, C. et al. (2012) Expression of serotonin receptors in human hepatocellular cancer.
    Clin Cancer Res. 18: 5902-10.

Synonyms
HTR7
RRID
AB_906118
UniProt
P34969
Entrez Gene
HTR7
GO Terms
GO:0005515 protein binding
GO:0004993 serotonin receptor activity
GO:0005887 integral to plasma membrane
GO:0007623 circadian rhythm
GO:0008015 blood circulation
View more products with 5-HT7 RECEPTOR specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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