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STAT3 Antibody

STAT3 Antibody gallery image 1

Western blot analysis of Jurkat cell lysate (lane 1 & 2), 3T3 cell lysate (lane 3) and rat kidney tissue lysate (lane 4) probed with Rabbit anti STAT3 antibody

  • STAT3 Antibody thumbnail image 1
  • Rabbit anti STAT3
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  • Product Type
    Polyclonal Antibody
  • Isotype
    Polyclonal IgG
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    AHP2350WBdatasheet pdfdatasheet pdf50 µg
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    • Rabbit anti STAT3 antibody recognizes signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, which plays an important role in cell growth, survival differentiation and transformation, transducing signals from cytokine receptors to the nucleus. STAT3 is phosphorylated my members of the Janus kinase (JAK) family in response to cytokines and growth factors including interleukin-5, interleukin-6, epidermal growth factor and leukaemia inhibitory factor. Phosphorylation results in STAT activation and the formation of STAT3 homo- or STAT3/STAT1 and STAT3/STAT5 heterodimers. STAT dimers translocate from the cytoplasm to the nucleus where they act as transcription factors. Deregulated JAK/STAT signaling has been implicated in a variety of cancers; STATs can regulate the tumor microenvironment and trigger a shift from cancer inhibition to promotion. STAT3 is expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Consistent STAT3 activation has been demonstrated to play a role in cell proliferation and tumor promoting inflammation.
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Western Blotting0.54.0 ug/ml

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
    • Immunofluorescence
    • Western Blotting
      Rabbit anti STAT3 antibody recognizes a band of approximately 97 kDa in Jurkat cell lysate, 3T3 cell lysate and rat kidney tissue lysate
    • Instructions For Use

    Additional STAT3 Antibody Formats

    Formats Applications Sizes available
    STAT3 Antibody : Purified WB 50 µg
    • Copyright © 2016 Bio-Rad

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      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

                • Product Images

                • STAT3 Antibody thumbnail image 1

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