Mouse Integrins and Cell Adhesion Molecules

CD62L (L-selectin) (MCA1259), expressed on leukocytes, takes part in their capture by the endothelium. The corresponding ligands are CD34 (MCA1825), MAdCAM-1 (MCA1551), and GlyCAM-1.

Image legend: Staining of WEHI cells with RAT ANTI-MOUSE CD34:RPE (MCA1825PE).

CD29 (ß1 integrin) (MCA2298), found on endothelial and epithelial cells, as well as all leukocytes, forms heterodimers with integrin a-subunits, including CD51 and CD49a-f.

CD31 (PECAM) (MCA2388), expressed on endothelial cells, platelets and most leukocyte populations. The primary ligand is avß3 integrin, but it also binds in a homophilic manner.

CD49a (a1 integrin) (MCA2301), expressed on activated T lymphocytes and monocytes, associates with the ß1 intergrin subunit to form CD49a/CD29 (VLA-1).


CD49d (a4 integrin) (MCA2294, MCA1230, MCA2082), expressed on most lymphocytes, can associate with either CD29 or ß7 integrin, primary ligands are CD106 (VCAM-1), fibronectin, and MAdCAM-1.

Image legend: Staining of mouse peripheral blood lymphocytes with RAT ANTI-MOUSE CD49d : Alexa Fluor® 488 (MCA2294A488).

CD49e (a5 integrin) (MCA2296, MCA2300), associates with CD29 to form the fibronectin receptor, CD49e/CD29 (VLA-5) VLA-5 found on mast cells, thymocytes, T cells and monocytes.

CD54 (ICAM-1) (MCA1371) is expressed on T cells, B cells, monocytes, and endothelial cells. It is ligand for LFA-1.

CD102 (ICAM-2) (MCA2295) is broadly expressed on most leukocytes and is constitutively expressed on endothelial cells. It is the ligand for LFA-1.

CD106 (VCAM-1) (MCA2297), expressed predominantly on endothelial cells, up-regulated during inflammation; binds CD49d.

CD107b (MAC-3 or LAMP-2) (MCA2293) is associated with lysosomal membranes and is primarily expressed on mononuclear phagocytes. As expression is predominantly cytoplasmic, flow cytometry analysis can be improved by using Leucoperm™.

Image Legend: Staining of mouse peritoneal macrophages with RAT ANTI-MOUSE CD107b:Alexa Fluor® 647 (MCA2293A647) following permeabilization with Leucoperm™ (BUF09).

CD147 (Basigin) (MCA2283) is found on leukocytes, red cells, platelets, and endothelial cells. CD147 binds to itself or a3ß1.

MAdCAM-1 (MCA1551) is expressed on endothelial cells within the mesenteric lymph nodes and the lamina propria of the intestine. It binds integrin a4ß7 and CD62L.

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