Infectious Salmon Anemia Virus (Isav) antibody | 4A11
ISAV was first identified in farmed salmon in Norway in 1984, spread by wild marine fish species, it has since been detected in farmed Atlantic salmon stocks throughout the North Atlantic, North West America and more recently in Chile, where it has also been detected in farmed Coho salmon (Godoy, M.G., et al. 2008). Due to the high mortality of infected individuals, ISAV has a significant ecconomic impact and infections are of serious concern to the aquaculture industry.
While the route of entry into the host, is as yet, poorly understood, evidence indicates that the virus enters through epithelial tissue in the gills (Weli, S.C., et al. 2013), this is similar to mammalian orthomyxoviruses which target respiratory tissues.
Clone 4A11can be used to identify ISAV in the tissues of infected fish and may be of use for research into methods for diagnosis and control of ISAV infections in the aquaculture industry.
- Target Species
- Product Form
- Tissue Culture Supernatant - liquid (concentrated)
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- ISAV isolate
- Approx. Protein Concentrations
- IgG concentration 0.5 - 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the Mouse SP2/0-Ag-14 myeloma cell line.
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Q8V3T7 Related reagents
- Q8V3U0 Related reagents
- Entrez Gene
- NP Related reagents
- HA Related reagents
- GO Terms
- GO:0003676 nucleic acid binding
- GO:0019012 virion
- GO:0042025 host cell nucleus
- GO:0016021 integral to membrane
- GO:0016787 hydrolase activity
- GO:0033644 host cell membrane
- For research purposes only
Applications of Infectious Salmon Anemia Virus (Isav) antibody
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
Secondary Antibodies Available
Useful Reagents Available
|Description||Product Code||Applications||Pack Size||List Price||Quantity|
|Rabbit anti Salmonid Ig||AHP761||E IF WB||50 µl|
|Mouse anti Salmonid Ig||MCA2182||E F IF WB||0.5 ml|
|Mouse anti Rainbow Trout Ig||MCA5976||C E IF WB||0.5 ml|
Product Specific References
Kent, M.L. (2000) Marine netpen farming leads to infections with some unusual parasites.
Int J Parasitol. 30: 321-6.
Aamelfot, M., et al. (2013) Characterisation of a monoclonal antibody detecting Atlantic salmon endothelial and red blood cells, and its association with the infectious salmon anaemia virus cell receptor.
J Anat. 222(5): 547-57.
Lyngstad, T.M., et al. (2012) Low virulent infectious salmon anaemia virus (ISAV-HPR0) is prevalent and geographically structured in Norwegian salmon farming.
Dis Aquat Organ. 101: 197-206.
Weli, S.C., et al. (2013) Infectious salmon anaemia virus infection of Atlantic salmon gill epithelial cells.
Virol J. 10: 5
Falk, K., et al. (1998) Characterization and applications of a monoclonal antibody against infectious salmon anaemia virus.
Dis. Aquat. Org. 34: 77-85.
Rimstad, E. et al. (2001) Characterization of the infectious salmon anemia virus genomic segment that encodes the putative hemagglutinin.
J Virol. 75 (11): 5352-6.
Godoy, M.G., et al. (2008) First detection, isolation and molecular characterization of infectious salmon anaemia virus associated with clinical disease in farmed Atlantic salmon (Salmo salar) in Chile.
BMC Vet Res. 4: 28.