Hepatitis B E Antigen antibody | HBe7
Mouse anti Hepatitis B E Antigen antibody, clone HBe7 recognizes the E antigen of the Hepatitis B virus (HBV). The E antigen is also known as HBeAg or precore antigen. It is one of two HBV core proteins and is secreted into the serum of infected patients, usually early on in the infection. Positive testing for HBeAg usually indicates active replication of HBV and is associated with in increased risk of hepatocellular carcinoma. HBeAg also elicits T cell tolerance and regulates the immune response to the intracellular nucleocapsid of the virus. This HBeAg-mediated immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by ion exchange chromatography from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Recombinant HBeAg.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- Shelf Life
- 18 months from date of despatch.
- For research purposes only
Applications of Hepatitis B E Antigen antibody
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Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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