Epstein-Barr Virus Nuclear Antigen antibody | 0211 (6F9/60)
Mouse anti Epstein-Barr Virus Nuclear Antigen antibody, clone 0211 recognizes Epstein-Barr Virus Nuclear Antigen, also known as EBNA-1. EBNA-1 is a 641 amino acid ~75 kDa viral protein required to maintain the EBV genomes in proliferating cells. It fulfils this role by binding to recognition sites in the FR and DS elements of the latent origin of DNA replication (oriP) within the episome. This promotes DNA replication and is involved with the partitioning of the episome during cell division and the activation of other viral latency genes.EBNA1 is able to avoid detection by cytotoxic T-lymphocytes which enables the persistence of latently infected cells that express EBNA1 in the absence of other EBV antigens.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Epstein-Barr virus.
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- Shelf Life
- 18 months from date of despatch.
- For research purposes only
Applications of Epstein-Barr Virus Nuclear Antigen antibody
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Paraffin 1|
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for Epstein-Barr Virus Nuclear Antigen antibody
Joshi, D.et al. (2009) Association of Epstein Barr Virus Infection (EBV) with Breast Cancer in Rural Indian Women.
PLoS ONE. 4: 1-8.
Tempera, I. et al. (2015) Identification of MEF2B, EBF1, and IL6R as Direct Gene Targets of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Critical for EBV-Infected B-Lymphocyte Survival.
J Virol. 90 (1): 345-55.
Hippocrate A et al. (2011) Possible role of EBV in breast cancer and other unusually EBV-associated cancers.
Cancer Lett. 305 (2): 144-9.