TWEAK antibody | MTW-1
Rat anti Mouse TWEAK antibody, clone MTW-1 recognizes mouse TWEAK (TNF-like weak inducer of apoptosis) a type II transmembrane TNF superfamily member. TWEAK binds to the TWEAK receptor FN14 (TWEAK-R) to weakly induce apoptosis in some cell types. It is involved in the induction of inflammatory cytokines. This cytokine also promotes proliferation and migration of endothelial cells and acts as a regulator of angiogenesis. TWEAK is expressed on a broad range of adult and foetal tissues. Rat anti Mouse TWEAK antibody, clone MTW-1 blocks ligand binding in vitro (Nakayama et al. 2003).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- O54907 Related reagents
- Entrez Gene
- Tnfsf12 Related reagents
- GO Terms
- GO:0005886 plasma membrane
- GO:0001525 angiogenesis
- GO:0006915 apoptosis
- GO:0016021 integral to membrane
- GO:0005125 cytokine activity
- GO:0005164 tumor necrosis factor receptor binding
- GO:0005615 extracellular space
- GO:0006955 immune response
- GO:0030154 cell differentiation
- For research purposes only
Applications of TWEAK antibody
|Application Name||Verified||Min Dilution||Max Dilution|
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
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Secondary Antibodies Available
|Description||Product Code||Pack Size||Applications||List Price||Quantity|
|Goat anti Rat IgG:Alk. Phos. (Mouse Adsorbed)||STAR131A||1 ml||C E P WB|
|Goat anti Rat IgG:Biotin (Mouse Adsorbed)||STAR131B||0.5 mg||C E IF P WB|
|Rabbit F(ab')2 anti Rat IgG:Dylight®800||STAR16D800GA||0.1 mg||F IF WB|
|Rabbit F(ab')2 anti Rat IgG:FITC||STAR17B||1 mg||F|
|Rabbit F(ab')2 anti Rat IgG:HRP||STAR21B||1 mg||C E P RE|
|Goat F(ab')2 anti Rat IgG:FITC (Mouse Adsorbed)||STAR69||0.5 ml||F|
|Goat anti Rat IgG:DyLight®649 (Mouse Adsorbed)||STAR71D649GA||0.1 mg||F IF|
|Goat anti Rat IgG:Dylight®800 (Mouse Adsorbed)||STAR71D800GA||0.1 mg||F IF WB|
|Goat anti Rat IgG:HRP (Mouse Adsorbed)||STAR72||0.5 mg||C E P|
|Goat F(ab')2 anti Rat IgG:RPE (Mouse Adsorbed)||STAR73||0.5 ml||F|
Product Specific References
Nakayama M et al. (2003) Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies.
Biochem Biophys Res Commun. 306 (4): 819-25.
References for TWEAK antibody
Kamata K et al. (2006) Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis.
J Immunol. 177 (9): 6433-9.
Kaduka, Y. et al. (2005) TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage.
Biochem Biophys Res Commun. 331 (2): 384-90.
Zimmerman, Z. et al. (2005) Effector cells derived from host CD8 memory T cells mediate rapid resistance against minor histocompatibility antigen-mismatched allogeneic marrow grafts without participation of perforin, Fas ligand, and the simultaneous inhibition of 3 tumor necrosis factor family effector pathways.
Biol Blood Marrow Transplant. 11 (8): 576-86.
Yoriki R et al. (2011) Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer.
Exp Ther Med. 2 (1): 103-108.
Frese-Schaper M et al. (2014) Influence of natural killer cells and perforin‑mediated cytolysis on the development of chemically induced lung cancer in A/J mice.
Cancer Immunol Immunother. 63 (6): 571-80.