Rat anti Mouse TWEAK antibody, clone MTW-1
recognizes mouse TWEAK (TNF-like weak inducer of apoptosis) a type II transmembrane TNF superfamily member. TWEAK binds to the TWEAK receptor FN14 (TWEAK-R) to weakly induce apoptosis in some cell types. It is involved in the induction of inflammatory cytokines. This cytokine also promotes proliferation and migration of endothelial cells and acts as a regulator of angiogenesis. TWEAK is expressed on a broad range of adult and foetal tissues. Rat anti Mouse TWEAK antibody, clone MTW-1 blocks ligand binding in vitro
(Nakayama et al. 2003
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Entrez Gene
- GO Terms
integral to membrane
tumor necrosis factor receptor binding
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of TWEAK antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
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Secondary Antibodies Available
Product Specific References
Nakayama M et al. (2003) Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies.
Biochem Biophys Res Commun. 306 (4): 819-25.
References for TWEAK antibody
Kamata K et al. (2006) Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis.
J Immunol. 177 (9): 6433-9.
Kaduka, Y. et al. (2005) TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage.
Biochem Biophys Res Commun. 331 (2): 384-90.
Zimmerman, Z. et al. (2005) Effector cells derived from host CD8 memory T cells mediate rapid resistance against minor histocompatibility antigen-mismatched allogeneic marrow grafts without participation of perforin, Fas ligand, and the simultaneous inhibition of 3 tumor necrosis factor family effector pathways.
Biol Blood Marrow Transplant. 11 (8): 576-86.
Yoriki R et al. (2011) Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer.
Exp Ther Med. 2 (1): 103-108.
Frese-Schaper M et al. (2014) Influence of natural killer cells and perforin‑mediated cytolysis on the development of chemically induced lung cancer in A/J mice.
Cancer Immunol Immunother. 63 (6): 571-80.