Rat anti mouse Interleukin-6 antibody, clone MP5-32C11 recognizes murine interleukin 6 (IL-6). IL-6 is a potent lymphoid cell growth factor which is principally expressed by macrophages and T-cells.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Recombinant mouse IL-6
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
interleukin-6 receptor binding
growth factor activity
external side of plasma membrane
endocrine pancreas development
defense response to protozoan
negative regulation of chemokine biosynthetic process
positive regulation of T-helper 2 cell differentiation
positive regulation of transcription, DNA-dependent
muscle cell homeostasis
negative regulation of hormone secretion
positive regulation of epithelial cell proliferation
branching involved in salivary gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
interleukin-6-mediated signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of IL-6 antibody
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Product Specific References
References for IL-6 antibody
Abrams, J.S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
Immunol Rev. 127: 5-24.
Bishop, G.A. et al. (2000) Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848.
J Immunol. 165 (10): 5552-7.
Boonstra, A. et al. (2000) UVB irradiation modulates systemic immune responses by affecting cytokine production of antigen-presenting cells.
Int Immunol. 12 (11): 1531-8.
Dohi, T. et al. (2001) Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis.
J Immunol. 167 (5): 2781-90.