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F4/80 antibody | Cl:A3-1

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MCA497
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C EM F IF IP P * R RE 2 ml loader
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Rat anti Mouse F4/80 antibody, clone A3-1 recognizes the murine F4/80 antigen, a ~160 kDa cell surface glycoprotein member of the EGF-TM7 family of proteins which shares 68% overall amino acid identity with human EGF module-containing mucin-like hormone receptor 1 (EMR1).

Expression of F4/80 is heterogeneous and is modulated during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans cells, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen (Hume, et al. 1984). F4/80 antigen is also expressed on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node (Gordon, et al. 1994). The ligands and biological functions of the F4/80 antigen have not been fully determined but a role for F4/80 in the generation of efferent CD8+ve regulatory T cells is proposed (Lin, et al. 2005)

Rat anti mouse F4/80 antibody, clone Cl:A3-1 modulates cytokine levels released in response to Listeria monocytogenes (Warschkau & Kiderlen, 1999).

A Human anti-idiotypic CI:A31 antibody, clone 17867 (HCA154 ) which binds to and blocks activity of Rat anti mouse F4/80 antibody, clone Cl:A3-1 is also available for use as a control in experiments utilizing clone A3-1.
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Our F4/80 (Cl:A3-1) Antibody has been referenced in >719 publications*


*Based on June 2020 data from CiteAb's antibody search engine.

Target Species
Mouse
Product Form
Tissue Culture Supernatant - liquid
Preparation
Tissue Culture Supernatant containing 0.2M Tris/HCl pH7.4 and 5-10% foetal calf serum
Buffer Solution
None present
Preservative Stabilisers
0.09%Sodium Azide
Immunogen
Thioglycollate stimulated peritoneal macrophages from C57BL/6 mice.
Fusion Partners
Spleen cells from immunized HOB2 rats were fused with cells of the mouse NS1 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry Neat 1/10
Immuno-electron Microscopy
Immunofluorescence
Immunohistology - Frozen
Immunohistology - Paraffin 1
Immunohistology - Resin
Immunoprecipitation
Radioimmunoassays
  1. 1 Rat anti Mouse F4/80 antibody, clone A3-1 requires pre-treatment of paraffin sections prior to staining. Proteinase K is recommended for tissues fixed for less than 24 hours. Citrate buffer pH 6.0 is recommended for tissues fixed for more than 24 hours. Please view the protocol at Antigen Retrieval Techniques.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

Flow Cytometry
Use 10ul of the suggested working dilution to label 106 cells in 100ul.

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Source Reference

  1. Austyn, J.M. & Gordon, S. (1981) F4/80, a monoclonal antibody directed specifically against the mouse macrophage.
    Eur J Immunol. 11 (10): 805-15.

Antibody Characterization Reference

  1. Hume, D.A. et al. (1984) The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia.
    Anat Rec. 210 (3): 503-12.
  2. Lee, S.H. et al. (1985) Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80.
    J Exp Med. 161 (3): 475-89.

References for F4/80 antibody

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    J Immunol. 163 (6): 3409-16.
  2. Moore, K.J. et al. (2000) Divergent response to LPS and bacteria in CD14-deficient murine macrophages.
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    J Physiol. 562 (Pt 3): 899-913.
  8. Lin, H.H. et al. (2005) The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance.
    J Exp Med. 201 (10): 1615-25.
  9. View The Latest Product References
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  118. Hasuzawa, N. et al. (2021) Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
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  119. Makiishi, S. et al. (2021) Carnitine/organic cation transporter 1 precipitates the progression of interstitial fibrosis through oxidative stress in diabetic nephropathy in mice.
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  264. Tarallo, V. et al. (2023) PlGF and VEGF-A/PlGF heterodimer are crucial in the recruitment and activation of immune cells during choroidal neovascularization.
    Res Sq. 22 Dec [Epub ahead of print].
  265. Turman, J.M. et al. (2021) Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via FcγRIIb on Liver Sinusoidal Endothelial Cells by Endocytosis.
    J Immunol. 206 (6): 1284-96.
  266. Kitagawa, K. et al. (2023) Subacute exposure to bisphenol F diglycidyl-ether induces chronic dermatitis characterized by psoriasis-like skin inflammation in mice.
    Genes Cells. 28 (1): 42-52.
  267. Chiozzi, P. et al. (2019) Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine.
    Sci Rep. 9 (1): 6475.
  268. Waasdorp, M. et al. (2019) Protease-activated receptor-1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy.
    J Cell Mol Med. 23 (2): 1268-1279.
  269. Hartley, G.P. et al. (2018) Programmed Cell Death Ligand 1 (PD-L1) Signaling Regulates Macrophage Proliferation and Activation.
    Cancer Immunol Res. 6 (10): 1260-73.
  270. Keller, S. et al. (2020) 9-Methyl-β-carboline inhibits monoamine oxidase activity and stimulates the expression of neurotrophic factors by astrocytes.
    J Neural Transm (Vienna). 127 (7): 999-1012.
  271. You, Y.K. et al. (2019) Petchiether A attenuates obstructive nephropathy by suppressing TGF-β/Smad3 and NF-κB signalling.
    J Cell Mol Med. 23 (8): 5576-87.
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  273. Li, J. et al. (2024) Mitophagy protects against silver nanoparticle-induced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome.
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Further Reading

  1. Gordon, S. et al. (1992) Antigen markers of macrophage differentiation in murine tissues.
    Curr Top Microbiol Immunol. 181: 1-37.

Flow Cytometry

Immuno-electron Microscopy

Immunofluorescence

Immunohistology - Frozen

Immunohistology - Paraffin

Western Blotting

RRID
AB_2335599
UniProt
Q61549
Entrez Gene
Emr1
GO Terms
GO:0005509 calcium ion binding
GO:0016021 integral to membrane
GO:0004930 G-protein coupled receptor activity
GO:0007218 neuropeptide signaling pathway
GO:0009897 external side of plasma membrane

MCA497

154568 1702 0413

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