CD73 antibody | TY/11.8

Rat anti Mouse CD73

Product Type
Monoclonal Antibody
Clone
TY/11.8
Isotype
IgG1
Specificity
CD73

Product Code Applications Pack Size List Price Your Price Qty
MCA6054GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Rat anti Mouse CD73 antibody, clone TY/11.8 recognizes CD73 also known as ecto-5′-nucleotidase. CD73 is a ~69 kDa GPI anchored surface protein. CD73, in combination with CD39, catalyzes the conversion of purine 5′ mononucleotides to nucleosides. CD73 was initially defined as a marker of regulatory T cells (Schuler et al. 2011).

Target Species
Mouse
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
CHO cells transfected with mouse CD73
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1/80 1/200
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10 μl of the suggested working dilution to label 1x106 cells in 100ul

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Description Goat F(ab')2 anti Rat IgG:FITC (Mouse Adsorbed)
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Description Goat anti Rat IgG:Dylight®800 (Mouse Adsorbed)
Goat anti Rat IgG:HRP (Mouse Adsorbed) STAR72 C E P 0.5 mg loader
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Description Goat anti Rat IgG:HRP (Mouse Adsorbed)
Goat F(ab')2 anti Rat IgG:RPE (Mouse Adsorbed) STAR73 F 0.5 ml loader
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Description Goat F(ab')2 anti Rat IgG:RPE (Mouse Adsorbed)

References for CD73 antibody

  1. Yoo, H.S. et al. (2013) Mesenchymal Stem Cell Lines Isolated by Different Isolation Methods Show Variations in the Regulation of Graft-versus-host Disease.
    Immune Netw. 13 (4): 133-40.

Further Reading

  1. Schuler PJ et al. (2011) Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets.
    J Immunol Methods. 369 (1-2): 59-68.

UniProt
Q61503
Entrez Gene
Nt5e
GO Terms
GO:0005886 plasma membrane
GO:0000166 nucleotide binding
GO:0005624 membrane fraction
GO:0006196 AMP catabolic process
GO:0008253 5'-nucleotidase activity
GO:0031225 anchored to membrane
GO:0046086 adenosine biosynthetic process
GO:0050728 negative regulation of inflammatory response
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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