Browsing Modes for Business Users

CD41 antibody | MWReg30

Rat anti Mouse CD41:Alexa Fluor® 488

Product Type
Monoclonal Antibody

Product Code Applications Pack Size List Price Your Price Qty
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F 100 Tests/1ml loader
List Price Your Price

Rat anti Mouse CD41 antibody, clone MWReg30 recognizes the mouse integrin alpha IIb subunit CD41. CD41 is a ~125 kDa single pass type 1 transmembrane glycoprotein expressed by platelets, megakaryocytes (Zhang et al. 2007), mast cells (Berlanga et al. 2005), and hematopoietic progenitors (Mitjavila-Garcia et al. 2002). CD41 forms a heterodimer with CD61.

The CD41/CD61 complex is important for platelet adhesion and aggregation (Patel et al. 2003) acting as a receptor for many extracellular matrix proteins including fibronectin, thrombospondin and vitronectin (Weisel et al. 1992).

Rat anti mouse CD41, clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al. 1999).

Target Species
Product Form
Purified IgG conjugated to Alexa Fluor® 488 - liquid
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
1% bovine serum albumin
Purified murine platelets
Approx. Protein Concentrations
Ig concentration 0.05 mg/ml
Max Ex/Em
Fluorophore Excitation Max (nm) Emission Max (nm)
Alexa Fluor®488 495 519
For research purposes only
12 months from date of despatch
This product is provided under an intellectual property licence from Life Technologies Corporation. The transfer of this product is contingent on the buyer using the purchased product solely in research, excluding contract research or any fee for service research, and the buyer must not sell or otherwise transfer this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; (c) manufacturing or quality assurance or quality control, or (d) resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad CA 92008 USA or

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry Neat
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10μl of the suggested working dilution to label 106 cells in 100μl.
The Fc region of monoclonal antibodies may bind to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (BUF041A/BUF041B).

How to Use the Spectraviewer

Watch the Tool Tutorial Video ▸
  • Start by selecting the application you are interested in, with the option to select an instrument from the drop down menu or create a customized instrument
  • Select the fluorophores or fluorescent proteins you want to include in your panel to check compatibility
  • Select the lasers and filters you wish to include
  • Select combined or multi-laser view to visualize the spectra

Description Product Code Applications Pack Size List Price Your Price Quantity
Mouse Seroblock FcR BUF041A F 0.1 mg loader
List Price Your Price
Description Mouse Seroblock FcR
Mouse Seroblock FcR BUF041B F 0.5 mg loader
List Price Your Price
Description Mouse Seroblock FcR

Source Reference

  1. Nieswandt, B. et al. (1999) Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice.
    Blood. 94 (2): 684-93.

References for CD41 antibody

  1. Larson, M.K. and Watson, S.P. (2006) Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3.
    Blood. 108: 1509-14.
  2. Tamagawa-Mineoka, R. et al. (2007) The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation.
    Am J Pathol. 170: 2019-29.
  3. Lutskiy, M.I. et al. (2007) WASP localizes to the membrane skeleton of platelets.
    Br J Haematol. 139: 98-105.
  4. Perez, L.E. et al. (2008) SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors.
    PLoS One. 3: e3565.
  5. Zanzinger, K. et al. (2009) Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes.
    Immunology. 128: 185-95.
  6. Winter, O. et al. (2010) Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow.
    Blood. 116: 1867-75.
  7. Takayama, M. et al. (2010) Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis.
    Mol Cell Biol. 30: 2668-80.
  8. Sullivan, B.P. et al. (2010) Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies.
    Toxicol Sci. 115: 286-94.
  9. View The Latest Product References
  10. Motohashi, H. et al. (2010) NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.
    Blood. 115 (3): 677-86.
  11. Göçmen, A.Y. et al. (2011) Effect of resveratrol on platelet activation in hypercholesterolemic rats: CD40-CD40L system as a potential target.
    Appl Physiol Nutr Metab. 36 (3): 323-30.
  12. Teeling, J.L. et al. (2012) Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction
    Acta Neuropathol. 124: 479-90.
  13. Fujita, R. et al. (2013) NF-E2 p45 Is Important for Establishing Normal Function of Platelets.
    Mol Cell Biol. 33: 2659-70.
  14. Goggs, R. et al. (2013) The small GTPase Rif is dispensable for platelet filopodia generation in mice.
    PLoS One. 8 (1): e54663.
  15. Woods, S.J. et al. (2015) Kinetic profiling of in vivo lung cellular inflammatory responses to mechanical ventilation.
    Am J Physiol Lung Cell Mol Physiol. 308 (9): L912-21.
  16. Flierl, U. et al. (2015) Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.
    J Exp Med. 212 (2): 129-37.
  17. Devanathan, V. et al. (2015) Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice.
    Proc Natl Acad Sci U S A. 112 (20): 6491-6.
  18. Cuccurullo, A. et al. (2016) Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis.
    PLoS One. 11 (3): e0151088.
  19. Ryan, J. et al. (2016) Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase.
    J Pathol. 238 (1): 10-20.
  20. Criel, M. et al. (2016) Absence of Pear1 does not affect murine platelet function in vivo.
    Thromb Res. 146: 76-83.
  21. Asai, J. et al. (2016) Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice.
    Am J Pathol. 186 (1): 101-8.
  22. Williams, C.M. et al. (2016) Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets.
    Platelets. 27 (4): 286-94.
  23. Thomson, A.K. et al. (2017) Survival of motor neurone protein is required for normal postnatal development of the spleen.
    J Anat. 230 (2): 337-46.
  24. Moore, S.F. et al. (2021) Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis.
    Int J Mol Sci. 22(19):10656.

Flow Cytometry


Entrez Gene
GO Terms
GO:0004872 receptor activity
GO:0008305 integrin complex
GO:0005925 focal adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0009897 external side of plasma membrane
GO:0050840 extracellular matrix binding



If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.

View more products with CD41 specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Mouse Products
Please note