CD339 antibody | HMJ1-29
Filter by Application:
F ResetHamster anti Mouse CD339
- Product Type
- Monoclonal Antibody
- Clone
- HMJ1-29
- Isotype
- IgG
- Specificity
- CD339
Antibody Quality and 
Unrivaled 
| Hamster anti Mouse CD339 antibody, clone HMJ1-29 specifically recognizes CD339, otherwise known as Jagged1, one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. In humans, mutations in the JAG1 gene are responsible for the autosomal dominant multisystem disorder Alagille syndrome 1 (ALGS1) |
- Target Species
- Mouse
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Jagged1-expressing CHO cells.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised Armenian hamsters were fused with cells of the P3U1 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
||
| Immunohistology - Frozen | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
- Histology Positive Control Tissue
- Mouse spleen
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| Goat F(ab')2 anti Hamster IgG:Dylight®800 | STAR104D800GA | F IF WB | 0.1 mg |
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| Description | Goat F(ab')2 anti Hamster IgG:Dylight®800 | ||||||
| Goat F(ab')2 anti Hamster IgG:FITC | STAR104F | F | 0.4 mg |
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| Description | Goat F(ab')2 anti Hamster IgG:FITC | ||||||
| Goat anti Hamster IgG:Biotin | STAR79B | E F | 0.8 mg |
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| Description | Goat anti Hamster IgG:Biotin | ||||||
| Goat anti Hamster IgG:FITC | STAR79F | F | 0.7 mg |
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| Description | Goat anti Hamster IgG:FITC | ||||||
| Goat anti Hamster IgG:HRP | STAR79P | E | 0.8 mg |
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| Description | Goat anti Hamster IgG:HRP | ||||||
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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| Hamster (Armenian) IgG Negative Control | MCA2356 | F | 0.25 mg |
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| Description | Hamster (Armenian) IgG Negative Control | ||||||
References for CD339 antibody
-
Moriyama Y et al. (2008) Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice.
Int Immunol. 20 (6): 763-73. -
Sekine, C. et al. (2009) Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands.
Int Immunol. 21 (3): 295-301. -
Sekine, C. et al. (2012) Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes.
Arthritis Res Ther. 14: R45. -
Koyanagi, A. et al. (2012) Expression of Notch receptors and ligands on immature and mature T cells.
Biochem Biophys Res Commun. 418: 799-805.
Further Reading
-
Bray, S.J. (2006) Notch signalling: a simple pathway becomes complex.
Nat Rev Mol Cell Biol. 7 (9): 678-89. -
Iso, T. et al. (2003) Notch signaling in vascular development.
Arterioscler Thromb Vasc Biol. 23 (4): 543-53. -
Hu, X. et al. (2008) Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.
Immunity. 29 (5): 691-703. -
Hoyne, G.F. et al. (2001) Notch signalling in the regulation of peripheral immunity.
Immunol Rev. 182: 215-27.
- Synonyms
- JAGGED1
- RRID
- AB_10709279
- UniProt
- Q9QXX0
- Q63722
- Entrez Gene
- Jag1
- Jag1
- GO Terms
- GO:0005886 plasma membrane
- GO:0005509 calcium ion binding
- GO:0001709 cell fate determination
- GO:0016021 integral to membrane
- GO:0005112 Notch binding
- GO:0007154 cell communication
- GO:0007219 Notch signaling pathway
- GO:0042127 regulation of cell proliferation
- GO:0042491 auditory receptor cell differentiation
- View More GO Terms
- GO:0045596 negative regulation of cell differentiation
- GO:0002011 morphogenesis of an epithelial sheet
- GO:0009887 organ morphogenesis
- GO:0045639 positive regulation of myeloid cell differentiation
- GO:0045747 positive regulation of Notch signaling pathway
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