Rat anti Mouse CD282 antibody, clone 6C2 recognizes the murine TLR2, otherwise known as CD282, a cell surface molecule that functions as a key receptor in the innate immune response. CD282 may interact functionally at the cell surface with TLR6.
Ligands for CD282 include bacterial cell wall components such as lipoproteins and peptidoglycans.
- Target Species
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- CHO cells expressing murine TLR2.
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
response to molecule of fungal origin
positive regulation of leukocyte migration
cell surface pattern recognition receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
integral to membrane
transmembrane receptor activity
defense response to Gram-positive bacterium
external side of plasma membrane
positive regulation of gene-specific transcription from RNA polymerase II promoter
phagocytic vesicle membrane
negative regulation of interleukin-12 production
negative regulation of interleukin-17 production
positive regulation of chemokine production
positive regulation of interferon-beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
negative regulation of growth of symbiont in host
Toll-like receptor 2-Toll-like receptor 6 protein complex
triacyl lipopeptide binding
diacyl lipopeptide binding
positive regulation of tumor necrosis factor biosynthetic process
innate immune response
positive regulation of nitric oxide biosynthetic process
protein heterodimerization activity
positive regulation of nitric-oxide synthase biosynthetic process
induction by symbiont of defense-related host nitric oxide production
positive regulation of macrophage cytokine production
lipoteichoic acid binding
cellular response to lipoteichoic acid
cellular response to peptidoglycan
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD282 antibody
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Negative Isotype Controls Available
Product Specific References
References for CD282 antibody
Kratzer, R. et al. (2010) Fusion proteins for versatile antigen targeting to cell surface receptors reveal differential capacity to prime immune responses.
J Immunol. 184 (12): 6855-64.
Patole, P.S. et al. (2006) Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice.
Nephrol Dial Transplant. 21 (11): 3062-73.
Mayer-Barber, K.D. et al. (2011) Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.
Immunity. 35 (6): 1023-34.
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