CD200R antibody | OX-110

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry			Neat

Flow Cytometry

Use 10μl of the suggested working dilution to label 10⁶ cells in 100μl.
The Fc region of monoclonal antibodies may bind to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (BUF041A/BUF041B).

Description	Product Code	Applications	Pack Size	List Price	Your Price	Quantity
Rat IgG2a Negative Control:Alexa Fluor® 647	MCA1212A647	F	100 Tests/1ml		Log in	- +	Add to Cart Get Quote Get Quote Add to Quote
List Price	Your Price
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Description	Rat IgG2a Negative Control:Alexa Fluor® 647

References for CD200R antibody

1. Wright, G.J. et al. (2003) Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.
   J Immunol. 171 (6): 3034-46.
2. Zhao, J. et al. (2009) Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice.
   PLoS Pathog. 5 (10): e1000636.
3. Björck, P. et al. (2011) Plasmacytoid Dendritic Cell Dichotomy: Identification of IFN-{alpha} Producing Cells as a Phenotypically and Functionally Distinct Subset.
   J Immunol. 186: 1477-85.
4. Dellacasa-Lindberg, I. et al. (2011) Migratory Activation of Primary Cortical Microglia upon Infection with Toxoplasma gondii.
   Infect Immun. 79: 3046-52.
5. Krejsek, J. et al. (2010) Expression of CD200/CD200R regulatory molecules on granulocytes and monocytes is modulated by cardiac surgical operation.
   Perfusion 25: 389-97.
6. Rijkers, E.S. et al. (2008) The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes.
   Mol Immunol. 45: 1126-35.
7. Costello, D.A. et al. (2011) Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation.
   J Biol Chem. 286 (40): 34722-32.
8. Simelyte, E. et al. (2008) CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.
   Arthritis Rheum. 58: 1038-43.
View The Latest Product References
9. Whitmore, L.C. et al. (2014) NOX2 protects against progressive lung injury and multiple organ dysfunction syndrome.
   Am J Physiol Lung Cell Mol Physiol. 307: L71-82.
10. Chitnis, T. et al. (2007) Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration.
    Am J Pathol. 170: 1695-712.
11. Larson, D. et al. (2012) Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner.
    J Immunol. 188: 4188-99.
12. Torrero, M.N. et al. (2009) CD200R surface expression as a marker of murine basophil activation.
    Clin Exp Allergy. 39 (3): 361-9.
13. Hernangómez M et al. (2012) CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation.
    Glia 60 (9): 1437-50.
14. Bain, C.C. & Mowat, A.M. (2012) CD200 receptor and macrophage function in the intestine.
    Immunobiology 217 (6): 643-51.
15. Seeds, R.E. et al. (2011) The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon.
    Int Immunopharmacol. 11 (7): 794-801.
16. Akkaya, M. et al. (2013) Dissection of agonistic and blocking effects of CD200 receptor antibodies.
    PLoS One 8 (5): e63325.
17. Cassard L et al. (2012) Fcγ receptors inhibit mouse and human basophil activation.
    J Immunol. 189 (6): 2995-3006.
18. Liu, J.Q. et al. (2016) A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma.
    J Immunol. Jul 6. pii: 1600052. [Epub ahead of print]
19. Toya, E.E. & Ohba, M. (2015) Improved Long-term Culture of Epidermal Stem Cells Utilizing CD200R-expressing Feeder Cells
    Showa Uni J Med Sci 27 (2) 83-91.
20. Lago, N. et al. (2018) CD200 modulates spinal cord injury neuroinflammation and outcome through CD200R1.
    Brain Behav Immun. 73: 416-26.
21. Qian, H. et al. (2023) Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice.
    Inflamm Res. 72 (12): 2127-44.

Flow Cytometry

Immunohistology - Frozen

Western Blotting

Synonyms

OX2R

RRID

AB_566615

UniProt

Q9ES57

Entrez Gene

Cd200r1

GO Terms

GO:0005515 protein binding

GO:0016021 integral to membrane

GO:0004872 receptor activity

GO:0009897 external side of plasma membrane

MCA2281A647

166583 1803

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