CD120a antibody | HM104
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Rat anti Mouse CD120a antibody, clone HM104 recognizes an extracellular region of mouse CD120a, also known as TNF receptor type I (TNFR1). TNFR1 is an ubiquitously expressed transmembrane glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily, which plays a key role in regulating the inflammatory response, acting as a receptor for tumor necrosis factor alpha (TNF-alpha) and lymphotoxin-alpha (TNF-beta).
CD120a also plays a role in apoptosis, cytokine induction, cell differentiation, tumor necrosis and early stages of graft-versus-host disease, and its soluble form sTNFR1, acts as an inhibitor of TNF-alpha induced responses by acting as a decoy receptor.
CD120a also plays a role in apoptosis, cytokine induction, cell differentiation, tumor necrosis and early stages of graft-versus-host disease, and its soluble form sTNFR1, acts as an inhibitor of TNF-alpha induced responses by acting as a decoy receptor.
Product Details
- Target Species
- Mouse
- Product Form
- Purified IgG conjugated to R. Phycoerythrin (RPE) - liquid
- Preparation
- Purified IgG prepared by ion exchange chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
Storage Information
- Storage
- Store at +4oC.
DO NOT FREEZE.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 6 months from date of despatch
More Information
- UniProt
- P25118
- Entrez Gene
- Tnfrsf1a
- GO Terms
- GO:0005886 plasma membrane
- GO:0042742 defense response to bacterium
- GO:0006915 apoptosis
- GO:0016021 integral to membrane
- GO:0005031 tumor necrosis factor receptor activity
- GO:0006693 prostaglandin metabolic process
- GO:0006954 inflammatory response
- GO:0045121 membrane raft
- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
- GO:0050729 positive regulation of inflammatory response
- Regulatory
- For research purposes only
Applications of CD120a antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | Neat |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Negative Isotype Controls Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Rat IgG2a Negative Control:RPE | MCA1212PE | F | 100 Tests |
|
Useful Reagents Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Mouse Seroblock FcR | BUF041A | F | 0.1 mg |
|
|
| Mouse Seroblock FcR | BUF041B | F | 0.5 mg |
|
Product Specific References
References for CD120a antibody
-
Pearl-Yafe, M. et al. (2010) Tumor necrosis factor receptors support murine hematopoietic progenitor function in the early stages of engraftment.
Stem Cells. 28 (7): 1270-80. -
Nakagawa, J. et al. (2007) TNF expressed by tumor-associated macrophages, but not microglia, can eliminate glioma.
Int J Oncol. 30 (4): 803-11.
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