ABCA1 antibody | 5A1-1422
Rat anti Mouse ABCA1:RPE
- Product Type
- Monoclonal Antibody
- Clone
- 5A1-1422
- Isotype
- IgG2a
- Specificity
- ABCA1
Rat anti Mouse ABCA1 antibody, clone 5A1.1422 recognizes murine adenosine triphosphate (ATP) Binding cassette transporter 1 (ABCA1). The ABC transporters are a large family of conserved proteins that transport a wide variety of molecules across cellular membranes. ABCA1 is a member of the ABC-A sub-family, which acts as a lipid translocator. The molecule was originally identified as a scavenger receptor on macrophages and research shows that ABCA1 also plays a major role in cholesterol metabolism. ABCA1 may play an important role in protecting against cardiovascular disease. Mutations in ABCA1 gene have been associated with Tangier disease, a genetic disorder of lipid metabolism, and the more common Familial HDL deficiency, peresenting with many of the same symproms. |
- Target Species
- Mouse
- Product Form
- Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
- Reconstitution
- Reconstitute with 1ml distilled water
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
5% Sucrose - Immunogen
- ABCA1 transfected HeLa cells.
- Max Ex/Em
-
Fluorophore Excitation Max (nm) Emission Max (nm) RPE 488nm laser 496 578 - Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | Neat |
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
How to Use the Spectraviewer
Watch the Tool Tutorial Video ▸- Start by selecting the application you are interested in, with the option to select an instrument from the drop down menu or create a customized instrument
- Select the fluorophores or fluorescent proteins you want to include in your panel to check compatibility
- Select the lasers and filters you wish to include
- Select combined or multi-laser view to visualize the spectra
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Rat IgG2a Negative Control:RPE | MCA1212PE | F | 100 Tests | Log in | |||
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Description | Rat IgG2a Negative Control:RPE |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Mouse Seroblock FcR | BUF041A | F | 0.1 mg | Log in | |||
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Mouse Seroblock FcR | BUF041B | F | 0.5 mg | Log in | |||
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Description | Mouse Seroblock FcR |
References for ABCA1 antibody
-
Pradel, L.C. et al. (2009) ATP-binding cassette transporter hallmarks tissue macrophages and modulates cytokine-triggered polarization programs.
Eur J Immunol. 39 (8): 2270-80. -
Wang, Y. et al. (2019) Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis.
Arterioscler Thromb Vasc Biol. 39 (5): 876-87.
Further Reading
-
Zarubica, A. et al. (2007) ABCA1, from pathology to membrane function.
Pflugers Arch. 453 (5): 569-79.
- RRID
- AB_2220006
- UniProt
- P41233
- Entrez Gene
- Abca1
- GO Terms
- GO:0002790 peptide secretion
- GO:0005887 integral to plasma membrane
- GO:0005524 ATP binding
- GO:0005548 phospholipid transporter activity
- GO:0005794 Golgi apparatus
- GO:0006497 protein lipidation
- GO:0006911 phagocytosis, engulfment
- GO:0008203 cholesterol metabolic process
- GO:0008509 anion transmembrane transporter activity
- View More GO Terms
- GO:0016887 ATPase activity
- GO:0010875 positive regulation of cholesterol efflux
- GO:0017127 cholesterol transporter activity
- GO:0033344 cholesterol efflux
- GO:0033700 phospholipid efflux
- GO:0043691 reverse cholesterol transport
- GO:0045332 phospholipid translocation
- GO:0071222 cellular response to lipopolysaccharide
- GO:0071300 cellular response to retinoic acid
MCA2681PE
151224If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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