XRN2 antibody | OTI5F4

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Mouse anti XRN2

Product Type
PrecisionAb Monoclonal
Clone
OTI5F4
Isotype
IgG2b
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00725
Datasheet
WB
SDS
100 µl loader

Mouse anti Human XRN2 antibody recognizes XRN2 , also known as DHP protein, 5'-3' exoribonuclease 2 and Dhm1-like protein (mouse homolog).

XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for XRN2; however, their full-length nature is not known (provided by RefSeq, Jul 2008).

Mouse anti Human XRN2 antibody detects a band of 110 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Mouse anti XRN2 detects a band of approximately 110 kDa in HepG2 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
Immunogen
E. coli-derived recombinant protein of amino acids 677-779 of human XRN2

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
Q9H0D6
Entrez Gene
XRN2
GO Terms
GO:0005515 protein binding
GO:0000738 DNA catabolic process, exonucleolytic
GO:0016049 cell growth
GO:0003676 nucleic acid binding
GO:0004534 5'-3' exoribonuclease activity
GO:0005730 nucleolus
GO:0006353 transcription termination, DNA-dependent
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0007283 spermatogenesis
GO:0008270 zinc ion binding
GO:0045449 regulation of transcription
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory
For research purposes only

Applications of XRN2 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml