WASL antibody | E02/4E10
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WB ResetMouse anti WASL
- Product Type
- PrecisionAb Monoclonal
- Clone
- E02/4E10
- Isotype
- IgG1
- Format
- Purified
- Specificity
- WASL
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| Mouse anti WASL antibody recognizes WAS/WASL-interacting protein family member 1, also known as WIPF1, PRPL-2, WIP. WASL is an important regulator of actin cytoskeleton assembly and remodelling, binding to and stabilizing the actin regulator Wiskott-Aldrich syndrome protein (WASp) (Ramesh et al. 1997). WASL also interacts with actin directly, an interaction found to be critical for plasticity of the actin cytoskeleton (Keppler et al. 2018). Through its role in actin regulation, it is involved with the activation and proliferation of cells. In its wider role, WASL is a multi-tasking protein within a network of protein-protein interactions (Sokolik et al. 2020). WASL is important for immune responses which depend on cellular functions requiring actin polymerization. Different roles for WASL have been identified in B cells, T cells, and natural killer cells. In these cell types, WASL deficiency has different consequences for cell proliferation, activation and function. Mutations in the WASL binding site cause Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) (Noy et al. 2012). |
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- Target Species
- Human
- Western Blotting
- Mouse anti WASL detects a band of approximately 67 kDa in MCF-7 cell lysates
- Species Cross-Reactivity
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Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-505 of human WASL
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/2000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- O43516
- Entrez Gene
- WIPF1
- GO Terms
- GO:0003779 actin binding
- GO:0005522 profilin binding
- GO:0006461 protein complex assembly
- GO:0008154 actin polymerization or depolymerization
- GO:0016023 cytoplasmic membrane-bounded vesicle
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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